Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells [PDF]
, 2015 G proteins and their cognate G protein-coupled receptors (GPCRs) function as critical signal transduction molecules that regulate cell survival, proliferation, motility and differentiation.
Aoki, J +15 more
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Analysis of Gq/G11 and G12/G13 mediated signalling in the endothelial functions [PDF]
, 2008 In this study, I analyzed the role of GPCR signalling pathways mediated by Gq/G11 and G12/G13 in the functions of the adult endothelium. To achieve endothelium specific deletion of G-alpha-q/11 and G-alpha-12/13, I crossed an inducible Tie2-Cre mouse ...
Korhonen, Hanna
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The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits [PDF]
, 2005 The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors.
Siderovski, David P. +1 more
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Molecular Determinants of Orexin Receptor Ligand Interaction : Studies on Ligand Selectivity and Impact of Calcium [PDF]
, 2014 Neuropeptides orexin-A and orexin-B, and their receptors OX1 and OX2 were first found as regulators of appetite, and later several other functions have been found as well.
Putula, Jaana
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS [PDF]
, 2010 Cardiovascular diseases are a major cause of mortality and morbidity in the developed countries. Anti-platelet therapy is a cornerstone treatment for patients with cardiovascular diseases.
Bhavaraju, Kamala
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Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets [PDF]
, 1999 Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the α-subunit of the heterotrimeric G protein Gq do not aggregate and degranulate but still undergo ...
Brandt, Ursula +4 more
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Analysis of diverse signal transduction pathways using the genetic model system Caenorhabditis elegans [PDF]
, 2003 Signal transduction allows cells to respond to signals from their environment and is therefore important for most biological processes. The binding of an extracellular signalling molecule to a cell-surface receptor is the first step in most signal ...
Moorman, Celine
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Leukemia-Associated Rho Guanine Nucleotide Exchange Factor Promotes G q-Coupled Activation of RhoA [PDF]
, 2002 Leukemia-associated Rho guanine-nucleotide exchange factor (LARG) belongs to the subfamily of Dbl homology RhoGEF proteins (including p115 RhoGEF and PDZ-RhoGEF) that possess amino-terminal regulator of G protein signaling (RGS) boxes also found within ...
Booden, M. A. +2 more
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Developing, optimizing and using FRET-based biosensors to elucidate G protein signaling [PDF]
, 2020 The aim of the research presented in this thesis was to gain a better understanding of how intracellular signaling by GPCRs is regulated. We used fluorescence microscopy to study GPCR signaling in live cells.
Mastop, M.
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Regulation of blood platelet function by nitric oxide [PDF]
, 2013 Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix resulting in platelet activation and aggregation to form a haemostatic plug.
Wake, Jonathan D.
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