Results 131 to 140 of about 104,548 (291)

The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

International Journal of Biological Sciences, 2005
The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane domain (7TM) cell-surface receptors.
doaj  

Modeling cell size regulation: From single-cell level statistics to molecular mechanisms and population level effects [PDF]

arXiv, 2018
Most microorganisms regulate their cell size. We review here some of the mathematical formulations of the problem of cell size regulation. We focus on coarse-grained stochastic models and the statistics they generate. We review the biologically relevant insights obtained from these models.
arxiv  

The elemental mechanism of transcriptional pausing. [PDF]

, 2019
Transcriptional pausing underlies regulation of cellular RNA biogenesis. A consensus pause sequence that acts on RNA polymerases (RNAPs) from bacteria to mammals halts RNAP in an elemental paused state from which longer-lived pauses can arise.
Chua, Xien Yu, Landick, Robert, Mishanina, Tatiana V, Mooney, Rachel Anne, Nayak, Dhananjaya, Saba, Jason, Windgassen, Tricia A   +6 more
core   +1 more source

Computational Modeling for the Activation Cycle of G-proteins by G-protein-coupled Receptors

, 2010
In this paper, we survey five different computational modeling methods. For comparison, we use the activation cycle of G-proteins that regulate cellular signaling events downstream of G-protein-coupled receptors (GPCRs) as a driving example.
Adriana Compagnoni, Alida Palmisano, Andrew D. Howard, Andrew Phillips, Andrew Phillips, Brian K. Kobilka, Corrado Priami, Federica Ciocchetta, Federica Ciocchetta, Gabriel Ciobanu, J'er^ome Feret, Jane Hillston, Janet D. Robishaw, John W. Pinney, Jos'e M. G. Vilar, Joseph Glavy, Joël Bockaert, Kristen L. Pierce, Louis M. Luttrell, Luca Cardelli, Luca Cardelli, Luca Cardelli, Luca Cardelli, Luca Cardelli, Maciej Koutny, Maria Luisa Guerriero, Mor Peleg, Nan Hao, Ozan Kahramanogullari, Tau M. Yi, Tommy White, William M. Oldham, Yifei Bao, Yifei Bao   +33 more
core   +2 more sources

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination [PDF]

, 2016
Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that ...
Asbagh, Layka Abbasi, Aushev, Vasily N, Baietti, Maria Francesca, Crowther, Jonathan, Lievens, Sam, Martínez García, David, Radaelli, Enrico, Sablina, Anna A, Simicek, Michal, Steklov, Mikhail, Tavernier, Jan   +10 more
core   +1 more source

A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension

Cytoskeleton, EarlyView.
Abstract Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and ...
Wan J. Gan, Rabina Giri, Jakob Begun, Helen E. Abud, Edna C. Hardeman, Peter W. Gunning, Alpha S. Yap, Ivar Noordstra   +7 more
wiley   +1 more source

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation

Current Research in Structural Biology
Molecular switches serve as key regulators of biological systems by acting as one of the crucial driving forces in the initiation of signal transduction pathway cascades.
Mahbub Hasan, Md. Nayem Sarker, Tazkia Jabin, Saifuddin Sarker, Shamim Ahmed, Mohammad Abdullah-Al-Shoeb, Tanvir Hossain   +6 more
doaj  

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

Cytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou, Maria C. Burns, Aynsley McDermott, Karolina Jaworek, Stacey J. Scott, James G. Wakefield, Lori Borgal   +6 more
wiley   +1 more source

Interaction Between Actin and Microtubules During Plant Development

Cytoskeleton, EarlyView.
ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu, Lidong Gao, M. Arif Ashraf, Qiong Nan   +3 more
wiley   +1 more source