Results 271 to 280 of about 154,453 (348)

Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation

Biochemical and Biophysical Research Communications, 2021
Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2.
Byong Seo Park, Hye Li Im, Nal Ae Yoon, Thai Hien Tu, Jeong Woo Park, Jae Geun Kim, Byung Ju Lee   +6 more
openaire   +2 more sources

Regulation of Protein Trafficking by GTP-Binding Proteins

, 2009
In eukaryotic cells, specific mechanisms allow selective packaging of proteins and lipids into transport vesicles, which can then specifically recognize the membrane of the acceptor compartment and fuse with it to deliver their cargo. Formation, transport and docking of vesicles are based on a complex network of interactions between regulatory ...
M. Franco, P. Chavrier, F. Niedergang
semanticscholar   +2 more sources

Small GTP-binding proteins and their regulators in cardiac hypertrophy

Journal of Molecular and Cellular Cardiology, 2008
Small GTP-binding proteins (small G proteins) act as GDP-GTP-regulated molecular switches and are activated by guanine nucleotide exchange factors (GEFs) in response to diverse extracellular stimuli. During this last decade, numerous molecular and cellular studies, as well as genetically-modified animal models, have highlighted the role of small G ...
Frank Lezoualc’h, Mélanie Metrich, Isabelle Hmitou, Nicolas Duquesnes, Éric Morel   +4 more
openalex   +3 more sources

Small GTP-binding Proteins—A New Family of Biologic Regulators

American Journal of Respiratory Cell and Molecular Biology, 1992
Alan Hall
openalex   +3 more sources

Common Properties of Receptors Coupled to GTP Binding Regulator Proteins

, 1989
A number of membrane receptors coupled to GTP binding regulatory proteins have recently been shown to share structural propertie at the level both of the genes and of the corresponding proteins (Fig. 1 and 2). By comparing results obtained for α2-, β1- and β2-adrenergic catecholamine receptors, M1 to M5 muscarinic acetylcholine receptors as well as ...
Laurent J. Emorine, Stéfano Marullo, Malène Sutren, C Delavier, Y. Eshdat, Graça Raposo, A. Donny Strosberg   +6 more
openalex   +2 more sources

Regulation of small GTP-binding proteins by insulin

Biochemical Society Transactions, 2006
Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins).
G I, Welsh, I, Hers, M, Wherlock, J M, Tavaré   +3 more
openaire   +2 more sources

DRG: A novel developmentally regulated GTP-binding protein

Biochemical and Biophysical Research Communications, 1992
Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein.
T, Sazuka, Y, Tomooka, Y, Ikawa, M, Noda, S, Kumar   +4 more
openaire   +2 more sources

Cellular responses regulated by rho-related small GTP-binding proteins

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1993
Rho-related proteins are members of the ras superfamily of small GTP-binding proteins. Their function in fibroblasts has been analysed using microinjection of living cells. Rho appears to link plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
A, Hall, H F, Paterson, P, Adamson, A J, Ridley   +3 more
openaire   +2 more sources

Tumour suppressors and the regulation of GTP-binding protein activity

Trends in Cell Biology, 1993
GTP-binding proteins regulate a wide variety of intracellular signalling pathways in eukaryotic cells. The Ras GTP-binding proteins have received a great deal of attention since they were found to be modified by amino acid substitutions in a large number of cancers.
I, Rey, A, Hall
openaire   +2 more sources

SOCS: negative regulators of cytokine signaling for immune tolerance.

International Immunology, 2021
Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase / signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding ...
A. Yoshimura, Minako Ito, S. Mise-Omata, M. Ando   +3 more
semanticscholar   +1 more source