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Regulation of small GTP-binding proteins by insulin [PDF]
Biochemical Society Transactions, 2006 Several members of the extensive family of small GTP-binding proteins are regulated by insulin, and have been implicated in insulin action on glucose uptake. These proteins are themselves negatively regulated by a series of specific GAPs (GTPase-activating proteins).
Ingeborg Hers +3 more
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Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation
Biochemical and Biophysical Research Communications, 2021Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2.
Nal Ae Yoon +7 more
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Regulators of Signal Transduction: Families of GTP-Binding Proteins
, 2019 Richard Kahn
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Regulation of Rod GTP Binding Protein by Guanine Nucleotides1
The Journal of Biochemistry, 1984The rod GTP-binding protein in the bovine disk membrane seems to exist as oligomers in the dark. G alpha and G beta do not interact strongly, and G gamma may be required for G alpha . GDP to dimerize.
Hitoshi Shichi, Robert L. Somers
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Tumour suppressors and the regulation of GTP-binding protein activity
Trends in Cell Biology, 1993GTP-binding proteins regulate a wide variety of intracellular signalling pathways in eukaryotic cells. The Ras GTP-binding proteins have received a great deal of attention since they were found to be modified by amino acid substitutions in a large number of cancers.
Isabelle Rey, Alan Hall
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DRG: A novel developmentally regulated GTP-binding protein
Biochemical and Biophysical Research Communications, 1992Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein.
Makoto Noda +4 more
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The GTP-binding protein, Go9 regulates neuronal calcium channels
Nature, 1987In neuronal cells, opioid peptides and opiates inhibit neurotransmitter release, which is a calcium-dependent process. They also inhibit adenylyl cyclase, presumably via the membrane signal-transducing component, Gi, a guanine nucleotide-binding protein (G-protein). No causal relationship between these two events has yet been demonstrated.
Günter Schultz +3 more
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SOCS: negative regulators of cytokine signaling for immune tolerance.
International Immunology, 2021Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase / signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding ...
A. Yoshimura +3 more
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Regulation of vesicular transport by GTP-binding proteins
Current Opinion in Nephrology and Hypertension, 1995Intracellular protein trafficking occurs in a series of transport vesicles. Vesicle trafficking is regulated both by heterotrimeric and monomeric GTP-binding proteins (G proteins). Recent studies have explored effector systems used by heterotrimeric G proteins and by monomeric ADP-ribosylation factor G proteins for regulation of vesicle budding.
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