Results 71 to 80 of about 104,022 (310)

The Small GTP-Binding Protein RhoA Regulates a Delayed Rectifier Potassium Channel [PDF]

Cell, 1998
Tyrosine kinases activated by G protein-coupled receptors can phosphorylate and thereby suppress the activity of the delayed rectifier potassium channel Kv1.2. Using a yeast two-hybrid screen, we identified the small GTP-binding protein RhoA as a necessary component in this process.
Ernest G. Peralta, Teresa G. Cachero, Anthony D. Morielli   +2 more
openaire   +3 more sources

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury

Advanced Science, EarlyView.
Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang, Shuang Shi, Shuo Liu, Yaqiong Jiao, Bin Huang, Yinghong Yang, Li Yang, Xinquan Yang, Hui Wang, Chunhui Liang, Dandan Song, Huaxiang Yu, Dan Zou, Qi Sun, Shu Yang, Chengqian Yin, Jian Li, Yiming Liu, Junxia Min, Fudi Wang, Yong Nian, Lutao Du, Bo Chu   +22 more
wiley   +1 more source

Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression. [PDF]

, 2012
A hallmark of all solid tumor malignancies is the ability to invade the surrounding tissue and/or metastasize to distant sites. Tumors cells have altered signaling pathways which that to cytoskeleton activation and migration.
Bourguignon, Lilly YW
core   +1 more source

Connecting protein and mRNA burst distributions for stochastic models of gene expression [PDF]

, 2011
The intrinsic stochasticity of gene expression can lead to large variability in protein levels for genetically identical cells. Such variability in protein levels can arise from infrequent synthesis of mRNAs which in turn give rise to bursts of protein expression. Protein expression occurring in bursts has indeed been observed experimentally and recent
arxiv   +1 more source

Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance. [PDF]

The Journal of general physiology, 1992
Beta-Adrenoceptor agonists activate a time- and voltage-independent Cl- conductance in mammalian cardiac myocytes. To characterize the cellular signaling pathways underlying its regulation, wide-tipped pipettes fitted with a pipette perfusion device were used to record whole-cell current and to introduce nucleotides to the interior of guinea pig ...
Tzyh Chang Hwang, David C. Gadsby, Minoru Horie, Angus C. Nairn   +3 more
openaire   +3 more sources

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

Co-expression of Gbeta 5 Enhances the Function of Two Ggamma Subunit-like Domain-containing Regulators of G Protein Signaling Proteins [PDF]

, 2000
Regulators of G protein signaling (RGS) stimulate the GTPase activity of G protein Galpha subunits and probably play additional roles. Some RGS proteins contain a Ggamma subunit-like (GGL) domain, which mediates a specific interaction with Gbeta 5. The
Chen, Ching-Kang, He, Wei, Kovoor, Abraham, Lester, Henry A., Simon, Melvin I., Wensel, Theodore G.   +5 more
core  

RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. [PDF]

, 2014
Partial agonists are used clinically to avoid overstimulation of receptor-mediated signalling, as they produce a submaximal response even at 100% receptor occupancy.
Chen, I-Shan, Furutani, Kazuharu, Inanobe, Atsushi, Kurachi, Yoshihisa   +3 more
core   +2 more sources

GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo [PDF]

BioEssays, 2007
AbstractRho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will
Bustelo, Xosé R., Sauzeau, Vincent, Berenjeno, Inmaculada M.   +2 more
openaire   +4 more sources

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Advanced Science, EarlyView.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming‐an Sun, Yanhua Li   +13 more
wiley   +1 more source