Results 61 to 70 of about 82,021 (288)

Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics [PDF]

Scientific Reports, 2017
AbstractThe mitotic spindle, essential for segregating the sister chromatids into the two evolving daughter cells, is composed of highly dynamic cytoskeletal filaments, the microtubules. The dynamics of microtubules are regulated by numerous microtubule associated proteins.
Schellhaus, A.K., Moreno-Andrés, D., Chugh, M., Yokoyama, H., Moschopoulou, A., De, S., Bono, F., Hipp, K., Schäffer, E., Antonin, W.   +9 more
openaire   +7 more sources

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo [PDF]

BioEssays, 2007
AbstractRho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will
Bustelo, Xosé R., Sauzeau, Vincent, Berenjeno, Inmaculada M.   +2 more
openaire   +3 more sources

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]

, 2014
Bis-(3 ',5 ') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence.
A Teplyakov, C Momany, C Saveanu, CD Boyd, CR Guzzo, D-G Ha, David Mackey, Delphine L. Caly, F Tao, GG Anderson, H Mulcahy, H Slater, H Sondermann, IS Pultz, J Duevel, J Mansfield, J Nesper, J. Maxwell Dow, Joseph Ward, K-H Chin, KB Twomey, Melanie Febrer, MY Galperin, R Hengge, Robert P. Ryan, RP Ryan, RP Ryan, RP Ryan, RP Ryan, RP Ryan, RP Ryan, S Moreau-Marquis, S-Q An, S-Q An, S-Q An, Sarah L. Murdoch, SE Maddocks, Shi-qi An, T Lundback, T Schirmer, U Romling, X Qiao, X-H Lu, Y Fouhy, Y McCarthy, Y McCarthy, Yvonne McCarthy   +46 more
core   +5 more sources

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Comparative analysis of blood whole transcriptome profiles in Yili horses pre- and post-5000-meter racing

Frontiers in Genetics
This study employed Yili horses participating in a 5000-meter race as a model to investigate exercise-induced gene expression alterations in peripheral blood using whole transcriptome sequencing.
Yi Su, Wanlu Ren, Wanlu Ren, Shikun Ma, Jun Meng, Jun Meng, Xinkui Yao, Xinkui Yao, Yaqi Zeng, Yaqi Zeng, Zexu Li, Luling Li, Ran Wang, Jianwen Wang, Jianwen Wang   +14 more
doaj   +1 more source

Tubulins in C. elegans [PDF]

, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source