EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, EarlyView.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking. [PDF]
J Cell Biolvan Vliet AR +6 more
europepmc +1 more source
ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner [PDF]
, 2011 Yongkang Yang +7 more
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The FEBS Journal, EarlyView.FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese +5 more
wiley +1 more source
Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution [PDF]
, 1999 Michael L. FITZGERALD, Guy L. REED
openalex +1 more source
Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale
Geriatrics &Gerontology International, EarlyView.ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi +4 more
wiley +1 more source
M-Ras distinct activation scenarios: A mechanistic outlook and targeting. [PDF]
Comput Struct Biotechnol JXu L, Liu Y, Jang H, Nussinov R.
europepmc +1 more source
In vitro mutation analysis of Arabidopsis thaliana small GTP‐binding proteins and detection of GAP‐like activities in plant cells [PDF]
, 1994 Toyoaki Anai +4 more
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Long‐term remission of type B insulin resistance syndrome with immunotherapy: A case report
Journal of Diabetes Investigation, EarlyView.ABSTRACT We report long‐term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55‐year‐old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high‐dose insulin and recombinant ...
Erika Egawa +3 more
wiley +1 more source
Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion. [PDF]
, 1996 Anjaneyulu Kowluru +8 more
openalex +1 more source