Results 191 to 200 of about 232,963 (342)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Conformational Rearrangement of Fission DSPs. [PDF]

Bioessays
Assembly properties of fission DSPs. Fission DSPs exist in a dynamic equilibrium of oligomer states in the cytosol, where they must be activated by partner proteins or lipid to induce assembly, and upon GTP hydrolysis, constriction. ABSTRACT Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes ...
Hutson AN, Rochon K, Mears JA.
europepmc   +2 more sources

Condition‐dependent resource allocation strategy governed by CodY regulator in Bacillus subtilis

mLife, EarlyView.
Abstract To thrive in nature, bacteria have to rapidly proliferate in favorable conditions while constantly adapt to the fluctuating nutrient environments. However, the molecular players that ensure rapid growth of bacteria in favorable conditions remain poorly understood.
Haoyan Mu, Yiheng Wang, Yongfu Pei, Xin Wang, Xiongfeng Dai, Manlu Zhu   +5 more
wiley   +1 more source

Molecular Determinants for Guanine Binding in GTP-Binding Proteins: A Data Mining and Quantum Chemical Study. [PDF]

Int J Mol Sci
Bhatta P, Hu X.
europepmc   +1 more source

RAP2B: a RAS-related GTP-binding protein from platelets. [PDF]

, 1990
C A Ohmstede, Francis X. Farrell, Bryan R. Reep, Kenneth J. Clemetson, E G Lapetina   +4 more
openalex   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Signal transduction through the GTP-binding proteins Rac and Rho [PDF]

, 1994
Anne J. Ridley
openalex   +1 more source

Glycoproteomics and Its Role in Understanding Bacterial O‐Linked Glycosylation

PROTEOMICS, EarlyView.
ABSTRACT Protein glycosylation is now recognized as a ubiquitous process observed in all domains of life. Within bacterial species, carbohydrates can be attached to multiple residues with glycosylation of serine, threonine, or tyrosine residues via their hydroxyl side chains referred to as O‐linked glycosylation.
Kristian I. Karlic, Hamza Tahir, Nichollas E. Scott   +2 more
wiley   +1 more source

Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits.

, 1989
Iok-Hou Pang, Paul C. Sternweis
openalex   +1 more source

Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins [PDF]

, 1992
Kazumasa Shiozaki, Tatsuya Haga
openalex   +1 more source