Results 201 to 210 of about 232,253 (352)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Involvement of GTP-binding Protein Immunologically Resembled G.ALPHA.s and G.ALPHA.olf in Phytoalexin Production of Cultured Carrot.

, 2002
Fumiya Kurosaki, Aoi Yamashita, Munehisa Arisawa   +2 more
openalex   +2 more sources

Identification of alpha 1-adrenergic receptors on sarcolemma from normal subjects and patients with idiopathic dilated cardiomyopathy: characteristics and linkage to GTP-binding protein. [PDF]

, 1989
Tarcisio Vago, Maurizio Bevilacqua, Guido Norbiato, Gabriella Baldi, Enrica Chebat, Pierluigi Bertora, G Baroldi, R. Accinni   +7 more
openalex   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

GTP-Binding Protein SAR1b [PDF]

, 2020
openaire   +1 more source

GTP-binding Proteins in Human Platelets

Platelets, 1990
K, Nagata, Y, Nozawa
openaire   +2 more sources

Characterization of GTP-binding proteins involved in the activation of phospholipase A2 by thrombin in rabbit platelets

, 1989
Yasuo Kajiyama, Toshihiko Murayama, Yasuyuki Nomura   +2 more
openalex   +1 more source

Immunoprecipitation of opioid receptor-Go-protein complexes using specific GTP-binding-protein antisera [PDF]

, 1995
Zafiroula Georgoussi, Graeme Milligan, C. Zioudrou   +2 more
openalex   +1 more source

Transcriptional Reinforcement of the HER2–RAS Network in HER2‐Positive Gastric Cancer: The RUNX–SOS1 Axis in Context

Cancer Science, EarlyView.
RUNX‐dependent transcriptional control of SOS1 reinforces HER2–RAS signaling and may attenuate responses to HER2‐targeted therapies in HER2‐positive gastric cancer. ABSTRACT HER2‐positive gastric cancer represents a distinct molecular subtype characterized by chromosomal instability, variable HER2 amplification, and substantial intratumoral ...
Tatsuya Masuda, Takayoshi Watanabe, Toshinori Ozaki, Yasuhiko Kamikubo   +3 more
wiley   +1 more source

Guanosine 5'‐(γ‐thio) triphosphate (GTPγS) inhibits phosphorylation of insulin receptor and a novel GTP‐binding protein, G_ir, from human placenta [PDF]

, 1994
Satish K. Srivastava, Tushar K. Varma, Ashish Sinha, Ugra S. Singh   +3 more
openalex   +1 more source