Results 201 to 210 of about 232,963 (342)

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

The involvement of GTP-binding protein in stimulus-induced platelet activation: Stimulatory effects on serotonin secretion and phospholipid metabolism.

, 1988
Shigeru Nakashima, Toyohiko Tohmatsu, Hiroaki Hattori, Akiyoshi Suganuma, Lisa Shirato, Atsuko Takenaka, Yoshihito Yawata, Yoshinori Nozawa   +7 more
openalex   +2 more sources

Isolation and Characterization of Extracellular Vesicles From Ascochyta rabiei, a Necrotrophic Fungal Chickpea Pathogen

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles produced by pathogenic organisms play a role in host recognition and invasion across kingdoms, including fungi interacting with their plant hosts. Little is known about EVs from phytopathogenic fungi compared to human fungal pathogens.
Matin Ghaheri, Chamindie Punyadeera, Ido Bar, Prabhakaran T. Sambasivam, Abolfazl Jangholi, Donovan Garcia‐Ceron, Muhammad J. A. Shiddiky, Rebecca Ford   +7 more
wiley   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein

, 1993
Mark A. Stamnes, James E. Rothman
openalex   +1 more source

Unraveling the Metabolic Influence of Olfactory Receptors in Cancer Cells

Sensory Neuroscience, EarlyView.
ORs are aberrantly expressed in various tumor types and regulate cancer cell metabolism through nonclassical signaling pathways, including PI3K/Akt, MAPK, and ERK. These receptors influence tumor proliferation, invasion, and immune evasion. Specific OR–ligand interactions offer promising opportunities for targeted cancer therapy and early diagnosis ...
Chengzhilin Li, Xiaochen Gao, Ziheng Liu, Nianlei Zhang, Xue Cao, Wenwen Qi, Chengcheng Liu   +6 more
wiley   +1 more source

VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins.

, 1994
Bruce Horazdovsky, G. Busch, Scott D. Emr   +2 more
openalex   +1 more source

GTP‐binding protein involvement in membrane currents evoked by carbachol and histamine in guinea‐pig ileal muscle. [PDF]

, 1992
S. Komori, Masaomi Kawai, Tadashi Takewaki, Hidenori Ohashi   +3 more
openalex   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source