Results 221 to 230 of about 231,218 (308)

Single-molecule fluorescence and cross-linking reveal ligand-gated Toc34 oligomerization dynamics. [PDF]

Biophys J
Penneru SK, Tiruvadi-Krishnan S, Lamichhane R, Bruce BD.   +3 more
europepmc   +1 more source

Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants

The FEBS Journal, EarlyView.
Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan, Jafar S. Jabbari, Naomi X. L. Ling, Anne M. Kong, Jia Q. Truong, Marnie L. Maddock, Ayeshah A. Rosdah, Christopher G. Langendorf, Lifang Zhang, Jarmon G. Lees, Sebastian Bass‐Stringer, Danise Ann Onda, Alice Pébay, Mirella Dottori, Kim Loh, Jessica K. Holien, Sean Lal, Nadia M. Davidson, Jonathan S. Oakhill, Shiang Y. Lim   +19 more
wiley   +1 more source

Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity. [PDF]

Nature
Vo AA, Modak A, Lu S, Blanchard SC, Lambert NA, Robertson MJ.   +5 more
europepmc   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Structural insights into Phospholipase Cε activity and regulation. [PDF]

J Biol Chem
Mahurkar KA, Barrios SL, McCauley FD, Lyon AM.   +3 more
europepmc   +1 more source

A novel adaptor protein, ARAP, orchestrates Fcγ receptor signaling in mouse dendritic cells via Rap1 activation and NF‐κB‐mediated cytokine production

Immunology &Cell Biology, EarlyView.
ARAP selectively regulates FcγR‐mediated signaling in dendritic cells. Loss of ARAP impairs phosphorylation of key signaling proteins, Rap1 activation, and integrin‐mediated adhesion, as well as NF‐κB p65 nuclear translocation and downstream cytokine production.
Chohee Park, Mi Jin Yu, Jong Ran Lee
wiley   +1 more source

Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer. [PDF]

Mol Cancer Ther
Price HE, Stauffer S, Lee H, Isanogle KA, Wu Y, Powell K, Baker A, Stauffer L, Perciaccante AJ, Jewell CP, Hernandez ER, Aljabri AK, Odeniyide P, Pratilas CA, Burgan W, Edmondson EF, Difilippantonio S, Kortum RL, Shern JF, Jenkins LM, Rossman KL, Yohe ME.   +21 more
europepmc   +1 more source

Expanding the Fish‐Brain Invitrome With the Senegalese Sole SsB‐1 Cell Line—A Versatile Model for Neurotropic Virus Research

Journal of Fish Diseases, EarlyView.
ABSTRACT Cell lines are essential tools for studying animal physiology and immunopathology, reducing the use of live animals and supporting the 3Rs principle of reduction, refinement, and replacement. The Senegalese sole (Solea senegalensis), a relevant species for Spanish aquaculture diversification, lacks established in vitro models. We developed SsB‐
Yulema Valero, Alberto Cuesta
wiley   +1 more source

The cytokinesis regulator RacGAP1 is a Rac1-specific GAP on membranes. [PDF]

Protein Sci
Dubois P, Ferrandez Y, Rey C, Pages C, Nawrotek A, Cherfils J.   +5 more
europepmc   +1 more source

Tolerance to Phosphorus Deficiency Improves Seed Phytic Acid‐to‐Iron Molar Ratios in Common Bean

Plant, Cell &Environment, EarlyView.
ABSTRACT Although significant advances have been achieved in the biofortification of common beans to overcome deficiencies in Zinc (Zn) and iron (Fe), the mechanisms involved remain poorly understood. We thus explored the relationships between phosphorus nutrition and Zn and Fe accumulation in four bean genotypes (Edar, Nizok, Colorado and Chimbolos ...
Barbara Karpinska, Christine H. Foyer
wiley   +1 more source