Results 231 to 240 of about 231,218 (308)

Unfolding ARF and ARL GTPases: from biophysics to systems-level insights. [PDF]

Front Mol Biosci
Quirion L, Strakhova R, Smith MJ, Côté JF.   +3 more
europepmc   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early <i>Legionella</i> infection. [PDF]

Proc Natl Acad Sci U S A
Im HN, Lee Y, Song Y, Hahn H, Jeon H, Shin D, Lee S, Kim KH, Kim KT, Suh SW, Jang DM, Kim HS.   +11 more
europepmc   +1 more source

The p21 GTP-binding proteins and bacterial toxins

International Journal of Medical Microbiology, 2000
openaire   +2 more sources

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

An evolutionarily conserved salt bridge stabilizes the active site for GTP hydrolysis in Rho GTPases. [PDF]

J Biol Chem
Marcus K, Schwabe M, Knihtila R, Mattos C.   +3 more
europepmc   +1 more source

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source

Oligomerization-dependent and synergistic regulation of Cdc42 GTPase cycling by a GEF and a GAP. [PDF]

EMBO Rep
Tschirpke S, Daalman WK, van Opstal F, Laan L.   +3 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking. [PDF]

J Cell Biol
van Vliet AR, Gillingham AK, Morgan TE, Ohashi Y, Smith TS, Abid Ali F, Munro S.   +6 more
europepmc   +1 more source