Results 261 to 270 of about 1,111,922 (385)

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

Molecular Biology of the Cell, 1996
Jim C. Norman, Leo S. Price, Anne J Ridley, A. Koffer   +3 more
semanticscholar   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

The crystal structure of Thermus thermophilus UMP kinase complexed with a phosphoryl group acceptor and donor. [PDF]

PLoS One
Fukui K, Nishiwaki A, Nakagawa N, Kuramitsu S, Masui R.   +4 more
europepmc   +1 more source

Alterations in mRNA levels, expression, and function of GTP-binding regulatory proteins in adipocytes from obese mice (C57BL/6J-ob/ob)

, 1991
Thomas W. Gettys, Vickram Ramkumar, Ronald J. Uhing, L. Seger, Ian L. Taylor   +4 more
openalex   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

The Rab3 family proteins in age-related neurodegeneration: unraveling molecular pathways and potential therapeutic targets. [PDF]

NPJ Aging
He H, Ai R, Fang EF, Palikaras K.
europepmc   +1 more source

A cAMP-regulated RNA-binding protein that interacts with phosphoenolpyruvate carboxykinase (GTP) mRNA.

, 1993
Nira Nachaliel, Deepti Jain, Y Hod
openalex   +1 more source

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.

Proceedings of the National Academy of Sciences of the United States of America, 1988
Jenny L. Sewell, R. A. Kahn
semanticscholar   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

Two specific interactions of GATE16 with TRPML3 and RAB33B regulate autophagy. [PDF]

Sci Rep
Park J, Choi A, Kwon J, Choi S, Park YM, Kim HJ.   +5 more
europepmc   +1 more source