Results 51 to 60 of about 1,111,922 (385)

Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins

Computational and Structural Biotechnology Journal, 2021
Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the activities of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors ...
Yuanhao Wang, Dong Ji, Chaoyu Lei, Yingfei Chen, Yuran Qiu, Xinyi Li, Mingyu Li, Duan Ni, Jun Pu, Jian Zhang, Qiang Fu, Yaqin Liu, Shaoyong Lu   +12 more
doaj   +1 more source

Activation of phospholipase C beta4 by heterotrimeric GTP-binding proteins [PDF]

, 1994
Transient transfection assays were used to determine how the activity of phospholipase C beta 4, which is preferentially expressed in retina, was regulated.
Jiang, Huiping, Simon, Melvin I., Wu, Dianqing   +2 more
core  

Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation [PDF]

, 2008
Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor ...
Berman, C.-K. Chen, Chan, Chen, Chen, Chen, Coleman, De Vries, Grafstein-Dunn, He, Heximer, K. C. Slep, Kimple, Koelle, Kozasa, Kozasa, Kudlacek, Lodowski, M. A. Kercher, M. I. Simon, McIntire, Neubig, Noel, P. B. Sigler, Slep, Snow, Sondek, Sunahara, T. Wieland, Tesmer, Tesmer, Valenzuela, Wang, Wilkie, Willars   +34 more
core   +4 more sources

Multiple GTP-binding proteins participate in clathrin-coated vesicle- mediated endocytosis

Journal of Cell Biology, 1993
We have examined the effects of various agonists and antagonists of GTP- binding proteins on receptor-mediated endocytosis in vitro. Stage- specific assays which distinguish coated pit assembly, invagination, and coat vesicle budding have been used to ...
Laura L. Carter, Thomas E. Redelmeier, Leslie A. Woollenweber, Sandra L. Schmid   +3 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Arends, Argan, Argan, Bogner, Bogner, Bradford, Böhni, Böhni, Chamberlain, Chen, Chen, Conboy, Eilers, Emr, Firgaira, Flügge, Frank, Gasser, Geller, Grossman, Gubler, Hanahan, Hansen, Harmey, Hartl, Hay, Hennig, Hennig, Horwich, Hurt, Hurt, Jaenicke, Keng, Kolanski, Maniatis, McAda, Miura, Miura, Mueckler, Nicholls, Nunberg, Ohta, Pelham, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Randall, Riezman, Roise, Rothblatt, Rothman, Schlenstedt, Schleyer, Schleyer, Schleyer, Schmidt, Schmidt, Schwaiger, Sebald, Stueber, van Loon, van Loon, Viebrock, Waters, Wiech, Wikstrom, Zimmermann, Zimmermann, Zwizinski, Zwizinski, Zwizinski   +72 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Co-crystalization reveals the interaction between AtYchF1 and ppGpp

Frontiers in Molecular Biosciences, 2022
AtYchF1 is an unconventional G-protein in Arabidopsis thaliana that exhibits relaxed nucleotide-binding specificity. The bindings between AtYchF1 and biomolecules including GTP, ATP, and 26S rRNA have been reported.
Ming-Yan Cheung, Xiaorong Li, Yee-Shan Ku, Zhongzhou Chen, Hon-Ming Lam   +4 more
doaj   +1 more source

The F-actin filament capping protein CapG is a bona fide nucleolar protein [PDF]

, 2008
Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus ...
Gettemans, Jan, Hubert, Thomas, Van Impe, Katrien, Vandekerckhove, Joël   +3 more
core   +2 more sources

A process model of Rho GTP-binding proteins

Theoretical Computer Science, 2009
AbstractRho GTP-binding proteins play a key role as molecular switches in many cellular activities. In response to extracellular stimuli and with the help of regulators (GEF, GAP, Effector, GDI), these proteins serve as switches that interact with their environment in a complex manner.
Kahramanogullari, Ozan, Luca Cardelli, Emmanuelle Caron, Philippa Gardner, Andrew Phillips   +4 more
openaire   +2 more sources