Results 51 to 60 of about 12,400 (144)
Plant Signaling & Behavior, 2022 Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo +7 more
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Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks? [PDF]
arXiv, 2006 In protein-protein interaction networks certain topological properties appear to be recurrent: networks maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper we investigate the role of protein disorder in the network topology.
arxiv
Expression Analysis of the Small GTP-Binding Protein Rac in Pterygium
Türk Oftalmoloji Dergisi, 2023 Objectives: To determine the roles of small GTP-binding proteins Rac1, Rac2, and Rac3 expression in pterygial tissue and to compare these expressions with normal conjunctival tissue.
Ahmet Saracaloğlu +6 more
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Refining the Protein-Protein Interactome using Gene Expression Data [PDF]
arXiv, 2010 Proteins interact with other proteins within biological pathways, forming connected subgraphs in the protein-protein interactome (PPI). Proteins are often involved in multiple biological pathways which complicates interpretation of interactions between proteins.
arxiv
Comparative structural dynamic analysis of GTPases.
PLoS Computational Biology, 2018 GTPases regulate a multitude of essential cellular processes ranging from movement and division to differentiation and neuronal activity. These ubiquitous enzymes operate by hydrolyzing GTP to GDP with associated conformational changes that modulate ...
Hongyang Li, Xin-Qiu Yao, Barry J Grant
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Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering
Scientific Reports, 2021 The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility.
Haider Khan +3 more
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Protein token: a dynamic unit in protein interactions [PDF]
arXiv, 2018 In this study, we introduced a new unit, named "protein token", as a dynamic protein structural unit for protein-protein interactions. Unlike the conventional structural units, protein token is not based on the sequential or spatial arrangement of residues, but comprises remote residues involved in cooperative conformational changes during protein ...
arxiv
Scientific Reports, 2017 Simple reversible competitive inhibition of nucleotide binding of GTP to Ras family GTPases has long been recognized as an unlikely approach to manipulating the activity of such proteins for experimental or therapeutic purposes.
Matthias P. Müller +4 more
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Global protein function prediction in protein-protein interaction networks [PDF]
Nature Biotech. 21, 697-700 (2003), 2003 The determination of protein functions is one of the most challenging problems of the post-genomic era. The sequencing of entire genomes and the possibility to access gene's co-expression patterns has moved the attention from the study of single proteins or small complexes to that of the entire proteome. In this context, the search for reliable methods
arxiv
Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana
Biomédica: revista del Instituto Nacional de Salud, 2010 En el fagosoma, Mycobacterium spp. altera la activación y reclutamiento de diferentes proteínas "del gen Ras de cerebro de rata", comúnmente conocidas como Rab.
Diana Castaño, Mauricio Rojas
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