Results 71 to 80 of about 216,354 (263)

Methods for Controlling Small GTPase Activity

ChemBioChem, Accepted Article.
Small GTPases comprise a diverse class of signaling proteins in mammalian cells and regulate a variety of cellular processes such as cell growth, cell movement, vesicle formation, and nuclear transport. Due to their involvement in critical cellular pathways, changes in the activation state of small GTPases due to genetic mutations or alterations in ...
Benjamin Faulkner, Yuchen He, Daniel Sitrin, Cliff Stains   +3 more
wiley   +1 more source

Chromenone derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, Accepted Article.
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Wolfgang Link, Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea-Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira   +10 more
wiley   +1 more source

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Selective [9‐15N] Guanosine for Nuclear Magnetic Resonance Studies of Large Ribonucleic Acids

ChemBioChem, EarlyView.
The small chemical shift anisotropy of nitrogen‐15 at the 9‐position in guanine (15N9‐G) leads to long T2 values and narrow NMR lines, particularly attractive to probe structure and dynamics of large (>200 nucleotide) ribonucleic acids (RNAs). RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that ...
Solomon K. Attionu, Rita Dill, Michael F. Summers, David A. Case, Jan Marchant, Theodore K. Dayie   +5 more
wiley   +1 more source

A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension

Cytoskeleton, EarlyView.
Abstract Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and ...
Wan J. Gan, Rabina Giri, Jakob Begun, Helen E. Abud, Edna C. Hardeman, Peter W. Gunning, Alpha S. Yap, Ivar Noordstra   +7 more
wiley   +1 more source

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

Cytoskeleton, EarlyView.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar, Joyeeta Chakraborty, Pananghat Gayathri, Ramanujam Srinivasan   +3 more
wiley   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

Cytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou, Maria C. Burns, Aynsley McDermott, Karolina Jaworek, Stacey J. Scott, James G. Wakefield, Lori Borgal   +6 more
wiley   +1 more source

Interaction Between Actin and Microtubules During Plant Development

Cytoskeleton, EarlyView.
ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu, Lidong Gao, M. Arif Ashraf, Qiong Nan   +3 more
wiley   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

ChemMedChem, EarlyView.
Small molecules form a covalent bond at KRAS tyrosine and inhibit its activation by guanine exchange factors in biochemical assays and mammalian cells. The development of the KRAS G12C inhibitor sotorasib is a major advance toward drugging KRAS. However, the G12C mutation is only found in about 10% of KRAS‐driven tumors. KRAS possesses several tyrosine
Alexander D. Landgraf, Robert Brenner, Mona K. Ghozayel, Khuchtumur Bum‐Erdene, Giovanni Gonzalez‐Gutierrez, Samy O. Meroueh   +5 more
wiley   +1 more source