Results 101 to 110 of about 68,431 (214)

GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression [PDF]

Journal of Biological Chemistry, 2009
GTP cyclohydrolase I (GTPCH) is a key enzyme in the synthesis of tetrahydrobiopterin (BH4), a required cofactor for nitricoxide synthases and aromatic amino acid hydroxylases. Alterations of GTPCH activity and BH4 availability play an important role in human disease.
Tatham, A, Crabtree, M, Warrick, N, Cai, S, Alp, N, Channon, K   +5 more
openaire   +2 more sources

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Osmar Vieira Ramires Júnior, Gustavo Ricardo Krupp Prauchner, Alessandra Schmitt Rieder, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela T. S. Wyse   +5 more
wiley   +1 more source

Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience [PDF]

, 2018
In every newborn with even mild hyperphenylalaninemia (HPA) tetrahydrobiopterin (BH4) deficiencies need to be excluded as soon as possible. Differential diagnosis is most commonly performed by analysis of urinary neopterin and biopterin.
Abu Seda, Bettina, Blau, Nenad, Hoffmann, Georg, Opladen, Thomas, Rassi, Anahita, Thöny, Beat   +5 more
core  

Bacterial fitness for plant colonization is influenced by plant growth substrate

New Phytologist, Volume 248, Issue 6, Page 3168-3190, December 2025.
Summary Despite advances in our understanding of bacterial plant colonization, the extent to which growth substrate influences the molecular mechanisms enabling bacteria to efficiently colonize plants remains poorly understood. To address this, we used randomly barcoded transposon mutagenesis sequencing (RB‐TnSeq) in Paraburkholderia graminis OAS925 ...
Marta Torres, Morgan N. Price, Albina Khasanova, Suzanne M. Kosina, Kateryna Zhalnina, Trent R. Northen, Adam M. Deutschbauer   +6 more
wiley   +1 more source

Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia [PDF]

, 2015
Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development. In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal supraphysiological ...
Fuenzalida, Bárbara, Gutiérrez, Jaime, Leiva, Andrea, Pardo, Fabián, Salomón, Carlos, Sanhueza, Carlos, Sobrevia, Luis, Toledo, Fernando, Westermeier, Francisco   +8 more
core   +4 more sources

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, Volume 12, Issue 42, November 13, 2025.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

Bioactive Compounds Derived From Natural Foods Against Metabolic Syndrome and the Advances of Resveratrol and Caffeic Acid in Microbial Cell Factory Production: A Review

Food Frontiers, Volume 6, Issue 6, Page 2575-2590, November 2025.
Metabolic syndrome is characterized by abdominal obesity, hyperglycemia, dyslipidemia, and hypertension. Bioactive compounds extracted from herbs, tea, and coffee using microbial cell factories, particularly resveratrol and caffeic acid, have demonstrated remarkable potential in the management of metabolic syndrome, offering innovative solutions for ...
Tao Li, Jingjing Shi, Tao Liu, Chongxiang Xue, Lin Han, Mingzhe Zhang, Linhua Zhao, Xiaolin Tong   +7 more
wiley   +1 more source

Effect of congenital reduced GCH1-function on sensitized and unsensitized pain [PDF]

, 2011
Hintergrund: Träger eines bestimmten Haplotyps des Gens der GTP Cyclohydrolase (GCH1) gaben im Anschluss an eine Diskektomie nach chronischer lumbaler Radikulopathie weniger Schmerzen an und hatten in experimentellen Schmerzmessungen höhere ...
Adolph, Jan
core  

Effect of Interferon-γ and LPS on Tetrahydrobiopterin in Rat PC 12 and Human KNA Cells

Pteridines, 2001
The first human phaeochromocytorna cell line KNA was tested with regard to stimulation of dopamine biosynthesis by nicotinamide adenine dinucleotide (NADH).
Vrecko Karoline, Pfragner Roswitha, Siegl Veronika, Schauenstein Konrad, Reibnegger Gilbert   +4 more
doaj   +1 more source

Cardiomyocyte‐Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aim Sirtuin 5 (SIRT5), a mitochondrial NAD+‐dependent deacylase, regulates fundamental cellular pathways, including energy substrate metabolism. The current study is designed to better elucidate the role of SIRT5 in the development of heart failure (HF). Methods Mice with cardiomyocyte‐specific deletion (cSirt5−/−) or overexpression (cSirt5‐Tg)
Nikole J. Byrne, Christoph Koentges, Katharina Pfeil, Julia C. Lueg, Sayan Bakshi, Aleksandre Tarkhnishvili, Ivan Vosko, Johannes Gollmer, Laura C. Birkle, Thomas Rathner, Stephan Birkle, Sibai Tang, Clara Rau, Michael M. Hoffmann, Katja E. Odening, Stephen Barnes, Landon Shay Wilson, Senka Ljubojevic‐Holzer, Markus Wallner, Dirk von Lewinski, Peter Rainer, Simon Sedej, Harald Sourij, Christoph Bode, Adam R. Wende, Andreas Zirlik, Heiko Bugger   +26 more
wiley   +1 more source