Flavin Biosynthesis Enhances Extracellular Electron Transfer in Bioengineered Escherichia coli
Advanced Science, Volume 13, Issue 2, 9 January 2026.Microbial electronics are promising for energy, sensing, environmental, and synthesis applications. E. coli are engineered with extracellular electron transfer (EET) pathways from a microbe that naturally produces current to enable bioelectronics based on E. coli.
Mohammed Mouhib +4 more
wiley +1 more source
Human GTP cyclohydrolase I: Only one out of three cDNA isoforms gives rise to the active enzyme. [PDF]
, 1994 GTP cyclohydrolase I catalyses the first and rate-limiting step of tetrahydrobiopterin biosynthesis. Its expression is regulated by interferon-γ or kit ligand in a tissue-specific manner.
Gütlich, M. +6 more
core
The Characterization of tRNA Modifying Enzymes S-adenosylmethionine : tRNA Ribosyltransferase-isomerase (QueA) and a novel Type I GTP cyclohydrolase [PDF]
, 2007 Queuosine is a hypermodified nucleoside located in the wobble position of bacterial and eukaryotic tRNAs coding for Asp, Tyr, His and Asn. The biosynthesis involves the participation of S-adenosyl-methionine:tRNA ribosyltransferase-isomerase (QueA) and a
Bonnett, Shilah Amal
core +2 more sources
Arquivos de Neuro-Psiquiatria, 2007 Dopa-responsive dystonia (DRD) is an inherited metabolic disorder now classified as DYT5 with two different biochemical defects: autosomal dominant GTP cyclohydrolase 1 (GCH1) deficiency or autosomal recessive tyrosine hydroxylase deficiency.
Rosana H. Scola +6 more
doaj +1 more source
Pteridines, 2000 The purpose of this study was to examine whether 17β-estradiol stimulates the synthesis of tetrahydrobiopterin : BH4), which is one of the cofactors of nitric oxide (NO) synthase, in mouse brain microvascular endothelial cells. Addition of 17()-estradiol
Shiota Kazuhiro +4 more
doaj +1 more source
GTP Cyclohydrolase I Phosphorylation and Interaction With GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide [PDF]
, 2010 Rationale: GTP cyclohydrolase I (GTPCH-1) is the rate-limiting enzyme involved in de novo biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for NO synthases and aromatic amino acid hydroxylases.
Kwon, Kihwan +7 more
core +1 more source
Biosynthesis of Methanopterin in Methanobacterium thermoautotrophicum
Pteridines, 1994 The early steps in the biosynthesis of methanopterin in Methanobacterium thennoautotrophicum were analyzed by in vivo incorporation experiments of 13C labeled precursors and by enzymatic studies.
Eisenreich Wolfgang, Bacher Adelbert
doaj +1 more source
Dopa-responsive dystonia and early-onset Parkinson's disease in a patient with GTP cyclohydrolase I deficiency? [PDF]
, 2006 We describe a patient with a combination of dystonic and parkinsonian signs. Paraclinical studies revealed a mutation in the GTP cyclohydrolase I gene (GCH1) and a decrease in [123I]-N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane
Nielsen, J.E. +9 more
core +1 more source
Promiscuous and Adaptable Enzymes Fill “Holes” in the Tetrahydrofolate Pathway in
mBio, 2014 Folates are tripartite molecules comprising pterin, para-aminobenzoate (PABA), and glutamate moieties, which are essential cofactors involved in DNA and amino acid synthesis.
Nancy E. Adams +8 more
doaj +1 more source
In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH4 Therapeutics. [PDF]
Int J Mol Sci, 2023 Hussein D.
europepmc +1 more source