Results 101 to 110 of about 5,611 (205)

Biochemical defect of the hph-1 mouse mutant is a deficiency in GTP-cyclohydrolase activity [PDF]

, 1988
Click on the link to access the article (may not be free).A hyperphenylalaninemic mouse mutant, hph-1, has been identified in the progeny of mice treated with the mutagen ethylnitrosourea. Phenylalanine hydroxylase activity levels in mutant liver lysates
Ledley, F.D., Bode, Vernon C., Jennings, I., Cotton, R.G., Woo, S.L., McDonald, J. David   +5 more
core  

Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1. [PDF]

, 2008
Endotoxin-related acute kidney injury has been shown to profoundly induce nitric oxide (NO), which activates sympathetic and renin-angiotensin system, resulting in renal vasoconstriction.
Wang, W, Sarah Faubel, Alp, N, Zhou, Z, Robert Schrier, Ra Summer, Zhu Zhou, Patricia Gengaro, Faubel, S, Or Falk, Summer, S, Gengaro, P, Channon, K, Schrier, R, Zolty, E, Falk, S, Einath Zolty, Keith Channon, Nicholas Alp, Wei Wang   +19 more
core   +1 more source

Serotonergic system in vivo with [¹¹C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients. [PDF]

Sci Rep, 2022
Timmers ER, Peretti DE, Smit M, de Jong BM, Dierckx RAJO, Kuiper A, de Koning TJ, Vállez García D, Tijssen MAJ.   +8 more
europepmc   +1 more source

Biosynthesis of riboflavin. Research of GTP cyclohydrolase II and 3,4-dihydroxy-2-butanon 4-phosphat synthase. [PDF]

, 2009
In der vorliegenden Arbeit wurden Informationen über GTP Cyclohydrolasen II und 3,4 Dihydroxy-2-butanon 4-phosphat Synthasen aus verschiedenen Organismen gewonnen.
Kraut, Stefan
core  

On the mechanism of action of GTP-transforming enzymes [PDF]

, 1997
Mechanisms for the ring conversion of GTP into cofactor precursors by GTP cyclohydrolases and molybdopterin synthase are proposed and discussed in the context of the crystal structure of the GTP cyclohydrolase I - 2'-deoxy-GTP complex.
Dufton, Mark J., Athmani, Salah, Andrew R. Pitt, Gibson, Colin L., Salah Athmani, Colin J. Suckling, Suckling, Colin J., Mark J. Dufton, Colin L. Gibson, Pitt, Andrew R.; id_orcid   +9 more
core   +1 more source

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype

Pteridines, 1993
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau Nenad, Thöny Beat, Heizmann Claus W., Dhondt Jean-Louis   +3 more
doaj   +1 more source

Lipopolysaccharide treatment in vivo induces tissue expression of GTP cyclohydrolase I mRNA [PDF]

, 1995
A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was observed in lung, heart and kidney of rats treated with lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in untreated rats, and remained elevated after LPS
Oka, Muneo, Muneo Oka, Nakanishi, Nobuo, Kasai, Kikuo, Shin-Ichi Shimoda, Shimoda, Shin-Ichi, Nobuo Nakanishi, Kikuo Kasai, Yoshiyuki Hattori, Hattori, Yoshiyuki   +9 more
core   +1 more source

Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production [PDF]

, 2008
GTP-cyclohydrolase 1 (GTP-CH1) catalyses the first and rate-limiting step for the de novo production of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthase (NOS).
Vallance, Patrick, Kelly, Peter, Nandi, Manasi, Leiper, James   +3 more
core   +1 more source

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth. [PDF]

Hypertension, 2021
Chuaiphichai S, Yu GZ, Tan CMJ, Whiteman C, Douglas G, Dickinson Y, Drydale EN, Appari M, Zhang W, Crabtree MJ, McNeill E, Hale AB, Lewandowski AJ, Alp NJ, Vatish M, Leeson P, Channon KM.   +16 more
europepmc   +1 more source

Expression of Concern. Shuangxi Wang, Jian Xu, Ping Song, Benoit Viollet, and Ming-Hui Zou. In Vivo Activation of AMP-Activated Protein Kinase Attenuates Diabetes-Enhanced Degradation of GTP Cyclohydrolase I. Diabetes 2009;58:1893-1901. DOI: 10.2337/db09-0267. PMID: 19528375. PMCID: PMC2712774. [PDF]

Diabetes, 2023
American Diabetes Association.
europepmc   +1 more source