Results 111 to 120 of about 5,611 (205)

GTP-cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP-CH1 deficiency: Identification and functional characterization of four novel mutations [PDF]

, 2004
GTP-cyclohydrolase I (GTP-CH1, EC 3.5.4.16) is encoded by the GCH1 gene. Mutations in the GCH1 gene cause both dopa-responsive dystonia (McKusick 128230) and recessive GTP-CH1 deficiency (McKusick 600225).
Viscardi V., Ghezzi D., Zorzi G., Saracino F., Nardocci N., Garavaglia B., Carbone M. L. A., Invernizzi F., Zeviani M.   +8 more
core   +1 more source

Inhibition of Brain GTP Cyclohydrolase I Attenuates 3-Nitropropionic Acid-Induced Striatal Toxicity: Involvement of Mas Receptor/PI3k/Akt/CREB/ BDNF Axis. [PDF]

Front Pharmacol, 2021
Mustafa AM, Rabie MA, Zaki HF, Shaheen AM.   +3 more
europepmc   +1 more source

Induction of GTP-cyclohydrolase I mRNA expression by lectin activation and interferon-γ treatment in human cells associated with the immune response. [PDF]

, 1993
The development of tetrahydrobiopterin synthesis during lectin stimulation of resting human T lymphocytes (Kerler et al. [1989] FEBS Lett., 250:622-624), the interferon-γ induced neopterin production by human monocytes/macrophages (Huber et al ...
Gütlich, M., Schott, K., Ziegler, I.
core  

Brain Transplantation of Neural Stem Cells Cotransduced with Tyrosine Hydroxylase and GTP Cyclohydrolase 1 in Parkinsonian Rats

Cell Transplantation, 2005
Neural stem cells (NSCs) of the central nervous system (CNS) recently have attracted a great deal of interest not only because of their importance in basic research on neural development, but also in terms of their therapeutic potential in neurological ...
M. Y. Ryu, M. A. Lee, Y. H. Ahn, K. S. Kim, S. H. Yoon, E. Y. Snyder, K. G. Cho M.D., Ph.D., S. U. Kim Ph.D.   +7 more
doaj   +1 more source

Influence of an Aromatic Amino Acid Decarboxylase Inhibitor on GTP Cyclohydrolase I Activity in the Rat Brain

Pteridines, 1997
Based on the hypothesis that catecholamine decreases may cause increases in biopterin, we measured the GTP cyclohydrolase I(GTPCH-I) activity and biopterin content in the cerebral cortex, midbrain/diencephalon, cerebeilum, pons/medulla oblongata ...
Sakamoto Hideo, Fujita Ko, Kuzuya Hiroshi   +2 more
doaj   +1 more source

Dopa-Responsive Dystonia Induced by a Recessive Gtp Cyclohydrolase I [PDF]

, 2008
GTP cyclohydrolase I (GTPCH) catalyzes the rate-limiting step of tetrahydrobiopterin (BH4) biosynthesis. GTPCH has been associated with two clinically distinct human diseases: the recessive hyperphenylalaninemia ( HPA) and the dominant dopa-responsive ...
HWU, WUH-LIANG, 胡務亮
core  

Co-expression of GTP cyclohydrolase I and aminodeoxychorismate synthase from alfalfa improves folate accumulation and plant growth in Lotus corniculatus

Environmental and Experimental Botany
Folate (vitamin B9) is an essential nutrient for livestock. However, natural folate levels in forage crops are often insufficient to meet livestock nutritional requirements.
Shan Feng, Ya-Ping Lin, Yi-Jun Cao, Ai-Ke Bao   +3 more
doaj   +1 more source

A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. [PDF]

Proc Natl Acad Sci U S A, 2020
Ebenhoch R, Prinz S, Kaltwasser S, Mills DJ, Meinecke R, Rübbelke M, Reinert D, Bauer M, Weixler L, Zeeb M, Vonck J, Nar H.   +11 more
europepmc   +1 more source

Subklonirovanie i issledovanie gena GTP-tsiklogidrolazy Bacillus subtilis. [PDF]

, 1991
International audienceBacillus subtilis GTP-cyclohydrolase gene and its deletion derivatives were subcloned in Escherichia coli cells. The position of the gene within the riboflavine operon was defined.
Batchikova, N V, Bidnenko, Vladimir E, Boretskiĭ, Iu R, Drobinskaia, I E, Rabinovich, P M   +4 more
core  

GTP cyclohydrolase I activity from Rickettsia monacensis strain Humboldt, a rickettsial endosymbiont of Ixodes pacificus. [PDF]

Ticks Tick Borne Dis, 2020
Bodnar J, Fitch S, Sanchez J, Lesser M, Baston DS, Zhong J.   +5 more
europepmc   +1 more source