Results 111 to 120 of about 68,431 (214)

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]

, 2017
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau, Nenad, Dhondt, Jean-Louis, Heizmann, Claus W., Thöny, Beat   +3 more
core  

Metabolic engineering of micronutrients in crop plants [PDF]

, 2016
Micronutrient deficiency is a widespread phenomenon, most prevalent in developing countries. Being causally linked to the occurrence of a range of diseases, it affects billions of people worldwide. Enhancing the content of micronutrients in crop products
Blancquaert, Dieter, De Steur, Hans, Gellynck, Xavier, Van Der Straeten, Dominique   +3 more
core   +2 more sources

BH4 Oxidation‐Derived H2O2 Activates ERK1/2 Signaling via B‐Raf in Rat Dorsal Root Ganglion Neurons

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Tetrahydrobiopterin (BH4) is linked to various pain conditions, but targeting its synthesis in vivo is prone to side effects. We now characterized a so far unknown mechanism of BH4‐induced signaling in sensory neurons. In rat dorsal root ganglion (DRG) neurons, we identified neither BH4 nor its oxidation product, BH2, but the byproduct H2O2 to induce ...
Milad Mohammadi, Maike Siobal, Jörg Isensee, Philipp N. Ostermann, Tim Hucho   +4 more
wiley   +1 more source

Dor crônica pós-operatória: fisiopatologia, fatores de risco e prevenção [PDF]

, 2011
BACKGROUND AND OBJECTIVES: Chronic postoperative pain (CPOP) prevalence is high, and is manifested both after minor and major surgeries. This subject has been increasingly studied. This study aimed at describing major aspects of this syndrome.
Clivatti, Jefferson, Leal, Plínio da Cunha, Sadatsune, Eduardo Jun, Sakata, Rioko Kimiko   +3 more
core   +1 more source

Negative Regulation of Insulin-induced Tetrahydrobiopterin Synthesis by Protein Kinase C in Vascular Endothelial Cells

Pteridines, 2001
We examined the role ofprotein kinase C (PKC) in the insulin-induced biosynthesis oftetrahydrobiopterin (BH4)' which is one of the co factors of nitric oxide (NO) synthase (NOS), in vascular endothelial cells. The BH. level was determined as biopterin by
Ishii Masakazu, Shimizu Shunichi, Nagai Tsutomu, Kazuhiro Shiota, Kiuchi Yuji, Yamamoto Toshinori   +5 more
doaj   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

Transcriptome Profile of Trichoderma harzianum IOC-3844 Induced by Sugarcane Bagasse [PDF]

, 2014
Profiling the transcriptome that underlies biomass degradation by the fungus Trichoderma harzianum allows the identification of gene sequences with potential application in enzymatic hydrolysis processing.
Crivelente Horta, Maria Augusta, Crucello, Aline, Cruz Pradella, Jose Geraldo da, Delabona, Priscila da Silva, Freitas, Sindelia, Kuroshu, Reginaldo Massanobu, Laborda, Prianda, Polikarpov, Igor, Souza, Anete Pereira, Vicentini, Renato   +9 more
core   +1 more source

Biosynthesis of Methanopterin in Methanobacterium thermoautotrophicum

Pteridines, 1994
The early steps in the biosynthesis of methanopterin in Methanobacterium thennoautotrophicum were analyzed by in vivo incorporation experiments of 13C labeled precursors and by enzymatic studies.
Eisenreich Wolfgang, Bacher Adelbert
doaj   +1 more source

Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression

Pharmaceuticals, 2019
Juvenile idiopathic arthritis (JIA) represents joint inflammation with an unknown cause that starts before the age of 16, resulting in stiff and painful joints. In addition, JIA patients often report symptoms of sickness behavior.
Gerdien A. H. Korte-Bouws, Eline Albers, Marije Voskamp, Hendrikus Hendriksen, Lidewij R. de Leeuw, Onur Güntürkün, Sytze de Roock, Sebastiaan J. Vastert, S. Mechiel Korte   +8 more
doaj   +1 more source

Identification and Characterization of Highly Fluorescent Pigment Cells in Embryos of the Arabian Killifish (Aphanius Dispar)

iScience, 2020
Summary: The Arabian killifish, Aphanius dispar, is a small tropical teleost fish living in wide range of habitats in sea water and fresh water in the Middle East.
Atyaf Hamied, Qusay Alnedawy, Ana Correia, Christian Hacker, Mark Ramsdale, Hisashi Hashimoto, Tetsuhiro Kudoh   +6 more
doaj   +1 more source