Results 181 to 190 of about 68,431 (214)

GTP-cyclohydrolase-I like immunoreactivity in rat brain

Brain Research, 1997
GTPCH-I immunoreactive structures in the rat brain were studied using a polyclonal antibody raised in the chick. General mapping was made using the avidin-biotin-peroxidase technique and compared with the distribution of tyrosine hydroxylase and serotonin immunoreactivities.
Dassesse, Donald, Cuvelier, Laetitia, Grégoire, Anne, Hemmens, Benjamin   +3 more
openaire   +2 more sources

Studies on GTP Cyclohydrolase I of Escherichia Coli

1993
GTP cyclohydrolase I (EC 3.5.4.16) has been obtained from Escherichia coli wild type cells by affinity chromatography.1,2 The gene coding for the enzyme from E. coli has been cloned and sequenced3,4 and has been mapped at 2251 kb of the physical map of the E.
Cornelia Schmid, Winfried Meining, Sevil Weinkauf, Luis Bachmann, Harald Ritz, Sabine Eberhardt, Wolfgang Gimbel, Thomas Werner, Hans-Werner Lahm, Herbert Nar, Adelbert Bacher   +10 more
openaire   +2 more sources

Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I

Journal of Molecular Biology, 2003
GTP cyclohydrolase I catalyses the hydrolytic release of formate from GTP followed by cyclization to dihydroneopterin triphosphate. The enzymes from bacteria and animals are homodecamers containing one zinc ion per subunit. Replacement of Cys110, Cys181, His112 or His113 of the enzyme from Escherichia coli by serine affords catalytically inactive ...
Nar, Herbert, Fischer, Markus, Rebelo, Jorge, Auerbach, Günter, Bracher, Andreas, Hösl, Cornelia, Bader, Gerd, Schramek, Nicholas, Kaiser, Johannes, Bacher, Adelbert, Huber, Robert   +10 more
openaire   +4 more sources

Mutations in GTP-cyclohydrolase I gene and vitiligo

The Lancet, 1997
Sporadic and familial cases of vitiligo, some of them associated with autoimmune endocrine disorders, have been described. Although an autosomal dominant inheritance with low penetrance is suspected, no genetic locus has yet been identified. It has been shown that tetrahydrobiopterin regulates melanin biosynthesis, and that patients with vitiligo have ...
openaire   +2 more sources

[192] GTP cyclohydrolase from Escherichia coli

1971
Publisher Summary The activity of GTP (guanosine triphosphate) cyclohydrolase is assessed most easily by measurement of the amount of formate released from GTP. A procedure is devised that results in the oxidation, either enzymatically or chemically of formate to carbon dioxide.
openaire   +1 more source

Detection and Quantification of GTP Cyclohydrolase I m RNA

1993
There is accumulating evidence that H4biopterin is synthesized in cells which do not depend on H4biopterin cofactor but undergo cytokine directed proliferation1. In this case, H4biopterin has a function which is apparently unrelated to its known cofactor role.
M, Gütlich, K, Schott, T, Werner, A, Bacher, I, Ziegler   +4 more
openaire   +2 more sources

GTP-cyclohydrolase and vitiligo

The Lancet, 1997
Karin U Schallreuter, Nenad Blau
openaire   +1 more source

Regulation of GTP Cyclohydrolase I by Estrogen

2002
Estrogens are well known for their protective effects on the cardiovascular system (1,2). Activation of estrogen receptors which have been identified in endothelial and vascular smooth muscle cells leads to changes in gene expression and alterations in cellular function (3,4).
Christian Hesslinger, Z. Chen, Amrita Ahluwalia, David L. Selwood, Patrick Vallance, Josef Pfeilschifter, Aroon D. Hingorani   +6 more
openaire   +1 more source

GTP Cyclohydrolase Regulation

2013
Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kondo   +4 more
openaire   +1 more source

GTP cyclohydrolase II

1991
Dietmar Schomburg, Margit Salzmann
openaire   +1 more source