Results 1 to 10 of about 80,775 (268)

Mycobacterium Fluoroquinolone Resistance Protein D (MfpD), a GTPase-Activating Protein of GTPase MfpB, Is Involved in Fluoroquinolones Potency. [PDF]

Microbiol Spectr, 2022
Tuberculosis (TB) caused by Mycobacterium tuberculosis infection remains one of the most serious global health problems. Fluoroquinolones (FQs) are an important component of drug regimens against multidrug-resistant tuberculosis, but challenged by the ...
Huang Y, Yan S, Li Y, Ai X, Yu X, Ge Y, Lv X, Fan L, Xie J.   +8 more
europepmc   +2 more sources

Novel Host Protein TBC1D16, a GTPase Activating Protein of Rab5C, Inhibits Prototype Foamy Virus Replication. [PDF]

Front Immunol, 2021
Prototype foamy virus (PFV) is a member of the oldest family of retroviruses and maintains lifelong latent infection in the host. The lifelong latent infection of PFV may be maintained by the restriction factors of viral replication in the host. However,
Yan J, Zheng Y, Yuan P, Wang S, Han S, Yin J, Peng B, Li Z, Sun Y, He X, Liu W.   +10 more
europepmc   +2 more sources

GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity. [PDF]

Nat Commun, 2021
Dysregulation of lipid metabolism and transport contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here the authors identify GP73 as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export ...
Peng Y, Zeng Q, Wan L, Ma E, Li H, Yang X, Zhang Y, Huang L, Lin H, Feng J, Xu Y, Li J, Liu M, Liu J, Lin C, Sun Z, Cheng G, Zhang X, Liu J, Li D, Wei M, Mo Y, Mu X, Deng X, Zhang D, Dong S, Huang H, Fang Y, Gao Q, Yang X, Wu F, Zhong H, Wei C.   +32 more
europepmc   +2 more sources

The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in Fusarium graminearium. [PDF]

Front Microbiol, 2021
Ypt1 is a small Rab GTPase in yeast, Gyp1 functions at the Golgi as a negative regulator of Ypt1. Gyp1 homologs are conserved in filamentous fungi. However, the roles of Gyp1 in phytopathogenic fungi are still unclear.
Zheng Q, Yu Z, Yuan Y, Sun D, Abubakar YS, Zhou J, Wang Z, Zheng H.   +7 more
europepmc   +2 more sources

Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in Fusarium graminearum. [PDF]

Front Microbiol, 2021
Zheng Q, Yu Z, Yuan Y, Sun D, Abubakar YS, Zhou J, Wang Z, Zheng H.   +7 more
europepmc   +2 more sources

Function of Rho GTPase Activating Protein 11A in Tumors. [PDF]

Chin Med J (Engl), 2018
Zhou HN, Ren YX, Li L, Wang KS, Jiao ZY.
europepmc   +2 more sources

Case Report: A Novel Missense Variant in the SIPA1L3 Gene Associated With Cataracts in a Chinese Family

Frontiers in Genetics, 2021
The signal-induced proliferation-associated 1-like 3 (SIPA1L3) gene that encodes a putative Rap GTPase-activating protein (RapGAP) has been associated with congenital cataract and eye development abnormalities.
Duo Yang, Haiyan Zhou, Jiwu Lin, Shuangxi Zhao, Hao Zhou, Zhaochu Yin, Bin Ni, Yong Chen, Wanqin Xie   +8 more
doaj   +1 more source

The roles of GTPase-activating proteins in regulated cell death and tumor immunity

Journal of Hematology & Oncology, 2021
GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form.
Hua He, Jingjing Huang, Sufang Wu, Shiyao Jiang, Lu Liang, Yueying Liu, Wenbing Liu, Li Xie, Yongguang Tao, Yiqun Jiang, Li Cong   +10 more
doaj   +1 more source

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. [PDF]

PLoS Genetics, 2012
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity.
Klodjan Stafa, Alzbeta Trancikova, Philip J Webber, Liliane Glauser, Andrew B West, Darren J Moore   +5 more
doaj   +1 more source

Barley ROP-Interactive Partner-a organizes into RAC1- and MICROTUBULE-ASSOCIATED ROP-GTPASE ACTIVATING PROTEIN 1-dependent membrane domains

BMC Plant Biology, 2020
Background Small ROP (also called RAC) GTPases are key factors in polar cell development and in interaction with the environment. ROP-Interactive Partner (RIP) proteins are predicted scaffold or ROP-effector proteins, which function downstream of ...
Caroline Hoefle, Christopher McCollum, Ralph Hückelhoven   +2 more
doaj   +1 more source