Results 121 to 130 of about 958,866 (334)

Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility.

PLoS Biology, 2019
Mutual gliding motility A (MglA), a small Ras-like GTPase; Mutual gliding motility B (MglB), its GTPase activating protein (GAP); and Required for Motility Response Regulator (RomR), a protein that contains a response regulator receiver domain, are major
Jyoti Baranwal, Sébastien Lhospice, Manil Kanade, Sukanya Chakraborty, Priyanka Rajendra Gade, Shrikant Harne, Julien Herrou, Tâm Mignot, Pananghat Gayathri   +8 more
doaj   +1 more source

Identification and partial purification of GTPase‐activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins [PDF]

, 1991
Tjie J. Tan, Petra Vollmer, Dieter Gallwitz   +2 more
openalex   +1 more source

Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin

EMBO Journal, 2014
In clathrin‐mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo‐specific adaptors for distinct cellular functions.
Liang Weng, A. Enomoto, H. Miyoshi, Kiyofumi Takahashi, N. Asai, N. Morone, P. Jiang, J. An, Takuya Kato, K. Kuroda, Takashi Watanabe, M. Asai, Maki Ishida-Takagishi, Y. Murakumo, H. Nakashima, K. Kaibuchi, Masahide Takahashi   +16 more
semanticscholar   +1 more source

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

Advanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng   +17 more
wiley   +1 more source

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis

Cell Reports, 2017
Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we 
Yiting Qiao, Jianxiang Chen, Ying Bena Lim, Megan Louise Finch-Edmondson, Veerabrahma Pratap Seshachalam, Lei Qin, Tingting Jiang, Boon Chuan Low, Himanshu Singh, Chwee Teck Lim, Marius Sudol   +10 more
doaj   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

RacGAP1 Plays an Oncogenic Role in Lung Adenocarcinoma by Regulating the Wnt/β-Catenin Pathway

Cells
Lung cancer is the most diagnosed cancer and the primary cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) becoming the prevalent histological subtype.
Nicola Mosca, Mariaceleste Pezzullo, Ilenia De Leo, Anna Truda, Giovanna Marchese, Aniello Russo, Nicoletta Potenza   +6 more
doaj   +1 more source

The IFT81-IFT74 complex acts as an unconventional RabL2 GTPase-activating protein during intraflagellar transport. [PDF]

EMBO J, 2023
Boegholm N, Petriman NA, Loureiro-López M, Wang J, Vela MIS, Liu B, Kanie T, Ng R, Jackson PK, Andersen JS, Lorentzen E.   +10 more
europepmc   +1 more source