Results 151 to 160 of about 958,866 (334)

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Current Biology, 2003
Andrew R. Tee, B. Manning, Philippe P Roux, L. Cantley, J. Blenis   +4 more
semanticscholar   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain. [PDF]

J Biol Chem, 2023
Héraud C, Pinault M, Neaud V, Saltel F, Lagrée V, Moreau V.   +5 more
europepmc   +1 more source

Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus

Journal of Cell Science, 2016
Nadia Jaber, N. Mohd-Naim, Ziqing Wang, J. Deleon, S. Kim, Hua Zhong, Namratha Sheshadri, Zhixun Dou, A. Edinger, G. Du, V. Braga, W. Zong   +11 more
semanticscholar   +1 more source

Chemigenetic Encoding of Fluorescent Dyes Enables High‐Fidelity and Wash‐Free Imaging of Proteins in Live Cells

Advanced Science, EarlyView.
This study develops a chemigenetic strategy that combines synthetic dyes with genetically encoded fluorescence for high‐fidelity, no‐wash protein imaging. By utilizing FRET between fluorescent proteins and Halo‐tag dyes, this system ensures that only target‐bound dyes fluoresce, effectively suppressing background signals and enhancing the signal‐to ...
Xuelian Zhou, Lu Miao, Ning Xu, Yonghui Chen, Jinjing Shi, Jinhua Zhou, Guangying Wang, Qinglong Qiao, Zhaochao Xu   +8 more
wiley   +1 more source

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

Interaction of two proline-rich sequences of cell adhesion kinase β with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf [PDF]

, 1998
Takeaki Ohba, Masaho Ishino, Hiroshi Aoto, Terukatsu Sasaki   +3 more
openalex   +1 more source

ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway

Advanced Science, EarlyView.
This study identifies STAU2 as an oncogenic RNA‐binding protein (RBP) with elevated expression in pancreatic ductal adenocarcinoma (PDAC), where its high levels are significantly correlated with metastatic progression. It elucidates that STAU2 directly binds and regulates PALLD, while mediating the functional role of IQGAP1, thereby driving metastasis ...
Jiayu Ding, Hao Shen, Jiaying Ji, Jiaxing Li, Zhongrui Shi, Xuejiao Wang, Bangbang Li, Yi Hou, Wenjian Min, Chengliang Sun, Kai Yuan, Yasheng Zhu, Liping Wang, Shun‐Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang   +16 more
wiley   +1 more source

Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma. [PDF]

Cancer Sci, 2021
Yoshimachi S, Shirakawa R, Cao M, Trinh DA, Gao P, Sakata N, Miyazaki K, Goto K, Miura T, Ariake K, Maeda S, Masuda K, Ishida M, Ohtsuka H, Unno M, Horiuchi H.   +15 more
europepmc   +1 more source