Results 11 to 20 of about 958,866 (334)
A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
Neuron, 1998 Hong-Jung Chen +3 more
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Corrigendum: The GTPase-Activating Protein FgGyp1 Is Important for Vegetative Growth, Conidiation, and Virulence and Negatively Regulates DON Biosynthesis in Fusarium graminearum [PDF]
Frontiers in Microbiology, 2021 Qiaojia Zheng +9 more
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Frontiers in Genetics, 2021 The signal-induced proliferation-associated 1-like 3 (SIPA1L3) gene that encodes a putative Rap GTPase-activating protein (RapGAP) has been associated with congenital cataract and eye development abnormalities.
Duo Yang +8 more
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GTPase-Activating Proteins for Cdc42 [PDF]
Eukaryotic Cell, 2002 ABSTRACT The Rho-type GTPase, Cdc42, has been implicated in a variety of functions in the yeast life cycle, including septin organization for cytokinesis, pheromone response, and haploid invasive growth. A group of proteins called GTPase-activating proteins (GAPs) catalyze the hydrolysis of GTP to GDP, thereby inactivating Cdc42.
Gregory R. Smith +3 more
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The roles of GTPase-activating proteins in regulated cell death and tumor immunity
Journal of Hematology & Oncology, 2021 GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form.
Hua He +10 more
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GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. [PDF]
PLoS Genetics, 2012 Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity.
Klodjan Stafa +5 more
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Modulation of small GTPase activity by NME proteins [PDF]
Laboratory Investigation, 2018 NME proteins are reported to influence signal transduction activity of small GTPases from the Ras superfamily by diverse mechanisms in addition to their generic NDP kinase activity, which replenishes the cytoplasmic pool of GTP. Comprehensive evidence shows that NME proteins modulate the activity of Ras GTPases, in particular members of the Rho family,
Vedrana Filić +3 more
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RAP1GAP (RAP1 GTPase activating protein) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on RAP1GAP (RAP1 GTPase activating protein), with data on DNA, on the protein encoded, and where the gene is implicated.
Chen, Z, Shao, X
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BMC Plant Biology, 2020 Background Small ROP (also called RAC) GTPases are key factors in polar cell development and in interaction with the environment. ROP-Interactive Partner (RIP) proteins are predicted scaffold or ROP-effector proteins, which function downstream of ...
Caroline Hoefle +2 more
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]
PLoS Computational Biology, 2006 Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
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