Results 231 to 240 of about 958,866 (334)

ARC Expands the DAAM1 Microexon‐Mediated Actin–RHOA/ROCK Interplay

Cytoskeleton, EarlyView.
ABSTRACT Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural‐specific microexon in DAAM1 in modulating actin's role in synaptic processes.
Patryk Poliński, Marta Miret Cuesta, Manuel Irimia   +2 more
wiley   +1 more source

Rho GTPase activating protein 21-mediated regulation of prostate cancer associated 3 gene in prostate cancer cell. [PDF]

Braz J Med Biol Res
Alves DA, Neves AF, Vecchi L, Souza TA, Vaz ER, Mota STS, Nicolau-Junior N, Goulart LR, Araújo TG.   +8 more
europepmc   +1 more source

Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis. [PDF]

Kidney Int, 2021
Li Q, Gulati A, Lemaire M, Nottoli T, Bale A, Tufro A.   +5 more
europepmc   +1 more source

Rho GTPase Control of Protein Kinase C-related Protein Kinase Activation by 3-Phosphoinositide-dependent Protein Kinase [PDF]

, 2000
Peter F. Flynn, Harry Mellor, Adele Casamassima, Peter J. Parker   +3 more
openalex   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

The Ras GTPase-activating protein UvGap1 orchestrates conidiogenesis and pathogenesis in the rice false smut fungus Ustilaginoidea virens. [PDF]

Mol Plant Pathol
Cao H, Gong H, Yu M, Pan X, Song T, Yu J, Qi Z, Du Y, Zhang R, Liu Y.   +9 more
europepmc   +1 more source

Together, Neuropilin 1 and Neuropilin 2 direct α5 integrin trafficking through GTPase-activating-protein p120RasGAP in endothelial cells to promote fibronectin fibrillogenesis

, 2023
Benwell C, Johnson R, Taylor J, Lambert J, Robinson S.   +4 more
europepmc   +1 more source

A protein kinase C‐independent pathway leading to c‐Jun‐dependent expression of 100‐kDa Ras GTPase‐activating protein in JEG‐3 human choriocarcinoma cells [PDF]

, 2000
Fei Ye, Marie‐Françoise Bourgeade, Yvon E. Cayre, Ming Nguy Thang   +3 more
openalex   +1 more source

Inhibition of the clathrin terminal domain – amphiphysin protein‐protein interaction. Probing the Pitstop® 2 aromatic moiety.

ChemMedChem, Accepted Article.
Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)‐4‐oxo‐4,5‐dihydrothiazol‐2‐yl)naphthalene‐1‐sulfonamide (1), inhibits the clathrin terminal domain‐ amphiphysin interaction (NTD‐PPI) and has been widely used to investigate endocytosis. In this work we report on the synthesis of 56 novel Pitstop 2 analogues via four discrete focused libraries.
Kate Prichard, Mark J Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J Robinson, Volker Haucke, Adam McCluskey   +10 more
wiley   +1 more source

Effect of Rho GTPase activating protein 9 combined with preoperative ratio of platelet distribution width to platelet count on prognosis of patients with serous ovarian cancer. [PDF]

Transl Cancer Res, 2021
Shen Y, Xu H, Guan Z, Lv M, Qian T, Wu Y.   +5 more
europepmc   +1 more source