Results 251 to 260 of about 14,319 (272)

GTPase activity of bacteriophage T4 sheath protein

Journal of Molecular Biology, 1992
We show by nuclear magnetic resonance studies that, following GTP hydrolysis during phage T4 sheath contraction, GDP remains bound to the sheath protein (gp18), whereas orthophosphate is released. gp18 in the contracted state has GTPase activity and can hydrolyse exogenous GTP; the reaction is calcium-dependent and displays high substrate specificity ...
I. V. Bartish, A. I. Tourkin, Poglazov Bf, Irina I. Serysheva   +3 more
openaire   +3 more sources

ARF GTPase-Activating Protein 1

2003
Regulators of Arf activity include a family of proteins with a shared domain, the cysteine-rich Arf GAP domain, that is responsible for activating the latent GTPase activity of Arfs. The first of these to be discovered, Arf GAP1 is the focus of this chapter.
Irit Huber, Dan Cassel, Edna Cukierman, Miriam Rotman   +3 more
openaire   +3 more sources

Rho GTPase-Activating Proteins in Cancer [PDF]

, 2009
Rho GTPases are involved in a variety of cellular functions and require strict regulation to insure proper signaling. As negative regulators of the Rho proteins, Rho GTPase-activating proteins (GAPs) also play critical roles in cytoskeleton regulation, cell-cycle control, gene expression, and normal development.
Matthew W. Grogg, Yi Zheng
openaire   +1 more source

RGS3 and RGS4 are GTPase Activating Proteins in the Heart

Journal of Molecular and Cellular Cardiology, 1998
RGS family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes when tested in vitro and in vivo.
Shaosong Zhang, Joseph E. Zahner, Jeffrey N. Rottman, Kendall J. Blumer, Ned Watson, Anthony J. Muslin   +5 more
openaire   +3 more sources

Bcr encodes a GTPase-activating protein for p21rac

Nature, 1991
More than thirty small guanine nucleotide-binding proteins related to the ras-encoded oncoprotein, termed Ras or p21ras, are known. They regulate many fundamental processes in all eukaryotic cells, such as growth, vesicle traffic and cytoskeletal organization.
Michelle D. Garrett, Christine Hall, Suzanne Brill, Dagmar Diekmann, Clinton Monfries, J. Justin Hsuan, Alan Hall, Nicholas F. Totty, Louis Lim   +8 more
openaire   +3 more sources

Rho GTPase-activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases

Molecular and Cellular Neuroscience, 2017
The Rho family of small GTPases was considered as molecular switches in regulating multiple cellular events, including cytoskeleton reorganization. The Rho GTPase-activating proteins (RhoGAPs) are one of the major families of Rho GTPase regulators.
Dong-Fu Feng, Zhao-Liang Sun, Hong-Jiang Li, Guo-Hui Huang   +3 more
openaire   +3 more sources

Rho GTPase Activating Proteins in Cancer Phenotypes

Current Protein & Peptide Science, 2006
Rho proteins belong to the Ras superfamily of small GTPases and function as binary switches that shuttle between active and inactive states based on the nature of bound guanine nucleotide. Three sets of regulatory proteins, namely, guanine dissociation inhibitors, guanine exchange factors, and GTPase activating proteins (GAPs) control the balance ...
openaire   +3 more sources

[8] Purification and properties of Rab3 GTPase-activating protein

2001
This chapter describes the assays for the Rab3 guanosine-5'-triphosphate (GTP)ase-activating proteins (GAP) activity, the procedures for the purification of native Rab3 GAP from rat brain synaptic soluble fraction, the procedures for the purification of recombinant hexahistidine (His6)-tagged Rab3 GAP from Escherichia coli, and the properties of Rab3
Takuya Sasaki, Yoshimi Takai, Fumiko Nagano   +2 more
openaire   +3 more sources

PDGF induction of tyrosine phosphorylation of GTPase activating protein [PDF]

Nature, 1989
The cascade of biochemical events triggered by growth factors and their receptors is central to understanding normal cell-growth regulation and its subversion in cancer. Ras proteins (p21ras) have been implicated in signal transduction pathways used by several growth factors, including platelet-derived growth factor (PDGF).
Stuart A. Aaronson, Jackson B. Gibbs, Christopher J. Molloy, Timothy P. Fleming, Donald P. Bottaro, Mark S. Marshall   +5 more
openaire   +2 more sources

Inhibition and Termination of Physiological Responses by GTPase Activating Proteins

Physiological Reviews, 2012
Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted in time; they need not only be initiated but also terminated.
Stefan Welti, Erzsébet Ligeti, Klaus Scheffzek   +2 more
openaire   +3 more sources