Results 261 to 270 of about 958,866 (334)
iMeta, EarlyView.scRiskCell is an interpretable intelligent computational framework that leverages nearly 500,000 islet cell expression profiles from 106 donors across different continuous disease states. By calculating the intrinsic relationship between donor disease states and cell expression profiles, it assigns a pseudo‐cell state index to each cell.
Xueqin Xie +7 more
wiley +1 more source
Pseudomonas aeruginosa ExoT Acts In Vivo as a GTPase-Activating Protein for RhoA, Rac1, and Cdc42 [PDF]
, 2002 Barbara I. Kazmierczak, Joanne N. Engel
openalex +1 more source
Mitochondrial dysfunction: Related diseases, influencing factors, and detection
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li +9 more
wiley +1 more source
Phosphoinositide-dependent Activation of the ADP-ribosylation Factor GTPase-activating Protein ASAP1
, 2000 Jeanelle L. Kam +8 more
openalex +1 more source
Endocytosis of Epidermal Growth Factor Receptor Regulated by Grb2-mediated Recruitment of the Rab5 GTPase-activating Protein RN-tre [PDF]
, 2002 Lenka Martinu +3 more
openalex +1 more source
PKN2 Inhibits VEGFA and bFGF‐Mediated Angiogenesis by Targeting HIF‐1α in Colon Cancer
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Angiogenesis plays a vital role in colon cancer growth and metastasis. The role of protein kinase N2 (PKN2) in colon cancer is rarely studied. In this study, we investigated the effect of PKN2 on angiogenesis in colon cancer. We evaluated the correlation between PKN2 expression and microvessel density (MVD) in tumor tissue of patients with ...
Yun Zhu +8 more
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley +1 more source
Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade Signaling
Medicine Bulletin, EarlyView.ABSTRACT Type I interferons (IFN‐Is) constitute the primary defense mechanism against pathogenic infections in the human body. The antiviral signaling mediated by IFN‐I is integral to the host immune response. Nevertheless, an imbalance in IFN‐I function can perturb the organism’s homeostasis. Consequently, it is imperative for the body to meticulously
Xiangjie Chen +3 more
wiley +1 more source
The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments. [PDF]
J Biol Chem, 2020 Chen PW +5 more
europepmc +1 more source