Results 21 to 30 of about 958,866 (334)

GTPase-Activating Protein

Definitions, 2020
The p2lr'z GTPase-activating protein (GAP) down-regulates p2lraS by stimulating its intrinsic GTPase activity. GAP is found predominantly as a monomer in the cytosol of normal cells.
Mark Jackman, Henrik J Ditzel, Morten F. Gjerstorff, Giovanni Blandino, Giorgia Randi, Stephan Ladisch, Jun Fujita, Angel Alonso, Celso A. Reis, I. Lubensky, O. Patel, Graham S. Baldwin, Arthur Shulkes, C. Tarn, Andrew K. Godwin, Christine Chaponnier, Helen L. Yin, Graziella Pratesi, Valerie Bosch, J. Landolph, Ruiwen Zhang, Roberta Vanni, Andrew P. Feinberg, Frank Saran, A. Vosough, Jane C-J Chao, Mutsuo Furihata, Tamotsu Takeuchi, Fritz Aberger, Weiling Zhao, Kenneth J Drake, Yogesh C. Awasthi, Sanjay Awasthi, Zhimin Yin, Goran Larson, J. Nilsson, Ammi Grahn, Z. Naor, Rony Seger, D. Michiel, David F. Nellis, T. Worzfeld, Stefan Offermanns, Ivan Damjanov, Jeffrey L. Platt, Alan L. Johnson, D. Woods, Manjinder Kaur, C. Agarwal, Rajesh Agarwal, Fujiki Hirota, T. G. del Pulgar, J. Lacal, Sara M. Johnson, B. Mark Evers, Giuseppe Lorenzo, Riccardo Autorino   +56 more
semanticscholar   +1 more source

A Novel GTPase-activating Protein for R-Ras [PDF]

Journal of Biological Chemistry, 1995
R-Ras, belonging to the Ras small GTP-binding protein superfamily, has been implicated in regulation of various cell functions such as gene expression, cell proliferation, and apoptotic cell death. In the present study, we purified an R-Ras-interacting protein with molecular mass of about 98 kDa (p98) from bovine brain cytosol by glutathione S ...
Masato Nakafuku, Kozo Kaibuchi, Takaharu Yamamoto, Takeshi Matsui, Akihiro Iwamatsu   +4 more
openaire   +3 more sources

Pseudomonas aeruginosa ExoT Is a Rho GTPase-Activating Protein

Infection and Immunity, 2000
Rebecca Krall, Gudula Schmidt, Klaus Aktories, Joseph Barbieri   +3 more
openalex   +2 more sources

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex

Journal of Cell Biology, 1996
Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins and ribnucleoproteins across the nuclear pore complex (NPC). A key regulator of the Ran GTP/GDP cycle is the 70-kD Ran-GTPase-activating protein RanGAP1.
M. Matunis, E. Coutavas, G. Blobel
semanticscholar   +1 more source

Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation*

Journal of Biological Chemistry, 2003
Insulin stimulates the rapid translocation of intracellular glucose transporters of the GLUT4 isotype to the plasma membrane in fat and muscle cells.
H. Sano, S. Kane, Eiko Sano, C. Mîinea, J. Asara, William Arbuthnot Sir Lane, C. W. Garner, G. Lienhard   +7 more
semanticscholar   +1 more source

The ADP-Ribosyltransferase Domain of the Effector Protein ExoS Inhibits Phagocytosis of Pseudomonas aeruginosa during Pneumonia

mBio, 2014
Pseudomonas aeruginosa is a Gram-negative pathogen commonly associated with nosocomial infections such as hospital-acquired pneumonia. It uses a type III secretion system to deliver effector proteins directly into the cytosol of host cells.
Stephanie M. Rangel, Latania K. Logan, Alan R. Hauser   +2 more
doaj   +1 more source

Transcriptome-based screening of intracellular pathways and angiogenesis related genes at different stages of thiram induced tibial lesions in broiler chickens

BMC Genomics, 2020
Background The Tibial dyschondroplasia (TD) in fast-growing chickens is mainly caused by improper blood circulation. The exact mechanism underlying angiogenesis and vascularization in tibial growth plate of broiler chickens remains unclear.
Ali Raza Jahejo, Ding Zhang, Sheng Niu, Raza Ali Mangi, Afrasyab Khan, Muhammad Farhan Qadir, Ajab Khan, Huan-chun Chen, Wen-xia Tian   +8 more
doaj   +1 more source

The interaction of Ras with GTPase‐activating proteins

FEBS Letters, 1997
Ras plays a major role as a molecular switch in many signal transduction pathways which lead to cell growth and differentiation. The GTPase reaction of Ras is of central importance in the function of the switch since it terminates Ras‐effector interactions.
Wittinghofer, A., Scheffzek, K., Ahmadian, M.   +2 more
openaire   +4 more sources

IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway

Tumor Biology, 2017
IQ-domain GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway.
Huan-Yu Zhao, Yang Han, Jian Wang, Lian-He Yang, Xiao-Ying Zheng, Jiang Du, Guang-Ping Wu, En-Hua Wang   +7 more
doaj   +1 more source

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Nature Communications, 2016
Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia, Jin-San Zhang, Fang Li, Jing Wang, Zhihui Deng, Mark A. White, Douglas G. Osborne, Christine Phillips-Krawczak, Timothy S. Gomez, Haiying Li, Amika Singla, Ezra Burstein, Daniel D. Billadeau, Michael K. Rosen   +13 more
doaj   +1 more source