Results 291 to 300 of about 958,866 (334)

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

open access: yesFASEB BioAdvances, EarlyView.
Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn   +5 more
wiley   +1 more source

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype

open access: yesAging Cell, EarlyView.
This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pipeline was developed to explore these subphenotypes, highlighting the importance of targeting metabolic redox circuits and serine/taurine pathways for ...
Domenica Berardi   +11 more
wiley   +1 more source

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

open access: yesAnnals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

open access: yesAndrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre   +5 more
wiley   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

open access: yesBrain Pathology, EarlyView.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li   +13 more
wiley   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li   +9 more
wiley   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin   +13 more
wiley   +1 more source

Opioid receptors in cardiovascular function

open access: yesBritish Journal of Pharmacology, EarlyView.
Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari   +4 more
wiley   +1 more source

GPCR‐G protein signalling and its mutational landscape in cancer—Driver or passenger

open access: yesBritish Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) play a crucial role in cellular signalling, regulating various physiological processes. Abnormal expression and mutations of GPCRs have been implicated in several types of cancer, influencing tumour initiation, progression and immune response.
Chenlin Feng   +3 more
wiley   +1 more source

GTPase-activating proteins and their complexes

Current Opinion in Structural Biology, 1998
In the past year, crystallographic structures for four complexes of GTPase-activating proteins (GAPs) with their target G proteins have been described and substantially enhance our understanding of how these proteins function. GAPs specific for the Rho and Ras families of small G proteins insert an arginine residue into the active site of the G protein,
Stephen J. Smerdon, Steven J. Gamblin
openaire   +3 more sources

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