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Rho GTPase-activating proteins in cell regulation [PDF]
Trends in Cell Biology, 2003 Rho family small GTPases serve as molecular switches involved in the regulation of diverse cellular functions including various cytoskeleton-related events and gene transcription. The Rho GTPase-activating proteins (RhoGAPs) are one of the major classes of regulators of Rho GTPases found in all eukaryotes that are crucial in cell cytoskeletal ...
Yi Zheng, Sun Young Moon
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p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13
, 1998Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the α subunits of certain heterotrimeric guanine nucleotide–binding proteins (G proteins). The guanine nucleotide exchange
T. Kozasa +7 more
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1993
Since Ras proteins negotiate many signalling pathways leading to cell growth or differentiation, the regulation of Ras activity is vital to cellular health. Ras activity, which derives from a collaboration between Ras and GTP, is terminated by the GTPase activating protein (GAP)-catalyzed hydrolysis of the GTP. Hence, a simple regulatory scheme emerges:
G Bollag, F McCormick
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Since Ras proteins negotiate many signalling pathways leading to cell growth or differentiation, the regulation of Ras activity is vital to cellular health. Ras activity, which derives from a collaboration between Ras and GTP, is terminated by the GTPase activating protein (GAP)-catalyzed hydrolysis of the GTP. Hence, a simple regulatory scheme emerges:
G Bollag, F McCormick
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Ras interaction with the GTPase‐activating protein (GAP)
Proteins: Structure, Function, and Bioinformatics, 1989AbstractBiologically active forms of Ras complexed to GTP can bind to the GTP ase‐activating protein (GAP), which has been implicated as a possible target of Ras in mammalian cells. In order to study the structural features of Ras required for this interaction, we have evaluated a series of mutant ras proteins for the ability to bind GAP and a series ...
Douglas Boylan +7 more
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Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.
Science, 1993The binding and hydrolysis of guanosine triphosphate (GTP) by the small GTP-binding protein Sar1p is required to form transport vesicles from the endoplasmic reticulum (ER) in Saccharomyces cerevisiae.
Tohru Yoshihisa +2 more
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GTPase activity of bacteriophage T4 sheath protein
Journal of Molecular Biology, 1992We show by nuclear magnetic resonance studies that, following GTP hydrolysis during phage T4 sheath contraction, GDP remains bound to the sheath protein (gp18), whereas orthophosphate is released. gp18 in the contracted state has GTPase activity and can hydrolyse exogenous GTP; the reaction is calcium-dependent and displays high substrate specificity ...
I. V. Bartish +3 more
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ARF GTPase-Activating Protein 1
2003Regulators of Arf activity include a family of proteins with a shared domain, the cysteine-rich Arf GAP domain, that is responsible for activating the latent GTPase activity of Arfs. The first of these to be discovered, Arf GAP1 is the focus of this chapter.
Irit Huber +3 more
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Rho GTPase-Activating Proteins in Cancer [PDF]
, 2009 Rho GTPases are involved in a variety of cellular functions and require strict regulation to insure proper signaling. As negative regulators of the Rho proteins, Rho GTPase-activating proteins (GAPs) also play critical roles in cytoskeleton regulation, cell-cycle control, gene expression, and normal development.
Matthew W. Grogg, Yi Zheng
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Bcr encodes a GTPase-activating protein for p21rac
Nature, 1991More than thirty small guanine nucleotide-binding proteins related to the ras-encoded oncoprotein, termed Ras or p21ras, are known. They regulate many fundamental processes in all eukaryotic cells, such as growth, vesicle traffic and cytoskeletal organization.
Michelle D. Garrett +8 more
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RGS3 and RGS4 are GTPase Activating Proteins in the Heart
Journal of Molecular and Cellular Cardiology, 1998RGS family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes when tested in vitro and in vivo.
Shaosong Zhang +5 more
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