Results 301 to 310 of about 137,270 (354)

Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies

Kasumi Suzuki, Yoshitaka Okawa, Sharmin Akter, Haruki Ito, Yoko Shiba   +4 more
openalex   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, EarlyView.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

The shibirets4 mutation causes temperature sensitive paralytic and lethal phenotypes in the Queensland fruit fly, Bactrocera tryoni

Insect Science, EarlyView.
Abstract Bactrocera tryoni, the Queensland fruit fly, is among the most damaging insect pests to the Australian horticultural industry as larvae infest ripening fruits or vegetables prior to harvest. Genetic biocontrol using Sterile Insect Technique (SIT) programs have been used to successfully suppress populations, via mass release of factory‐reared ...
Anzu Okada, Mamoru Okamoto, Thu N.M. Nguyen, Elisabeth Fung, Han Nguyen, Peter Crisp, Amanda Choo, Simon W. Baxter   +7 more
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

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GTPase-activating proteins and their complexes

Current Opinion in Structural Biology, 1998
In the past year, crystallographic structures for four complexes of GTPase-activating proteins (GAPs) with their target G proteins have been described and substantially enhance our understanding of how these proteins function. GAPs specific for the Rho and Ras families of small G proteins insert an arginine residue into the active site of the G protein,
S J, Gamblin, S J, Smerdon
openaire   +2 more sources

ARF GTPase-Activating Protein 1

2003
Regulators of Arf activity include a family of proteins with a shared domain, the cysteine-rich Arf GAP domain, that is responsible for activating the latent GTPase activity of Arfs. The first of these to be discovered, Arf GAP1 is the focus of this chapter.
Irit, Huber, Edna, Cukierman, Miriam, Rotman, Dan, Cassel   +3 more
openaire   +2 more sources

GTPase activating proteins.

Seminars in cancer biology, 1992
Since Ras proteins negotiate many signalling pathways leading to cell growth or differentiation, the regulation of Ras activity is vital to cellular health. Ras activity, which derives from a collaboration between Ras and GTP, is terminated by the GTPase activating protein (GAP)-catalyzed hydrolysis of the GTP. Hence, a simple regulatory scheme emerges:
G, Bollag, F, McCormick
openaire   +1 more source

GTPase Activating Proteins

1993
Small GTPases such as ras p21 have low intrinsic GTPase activity and depend on GTPase activating proteins (GAPs) to convent their active GTP-bound forms to their inactive GDP-bound counterparts (Bollag and McCormick 1991b). GAPs therefore appear to be major negative regulators of these GTPases (Fig. 1).
openaire   +1 more source

Chick kainate binding protein lacks GTPase activity

NeuroReport, 1999
Chick kainate binding protein was solubilized from cerebellar membranes and purified (x19) by use of two chromatographic steps. Measurements of [3H]kainate binding and GTPase activity in the different fractions reveal a consistent decrease of GTPase activity as the purification proceeds so that no GTPase is detectable after the final purification step.
Tasca, C.I., Burgos, J.S., Barat, A., Souza, D.O., Ramírez Jofré, Galo   +4 more
openaire   +3 more sources

GTPase activity of bacteriophage T4 sheath protein

Journal of Molecular Biology, 1992
We show by nuclear magnetic resonance studies that, following GTP hydrolysis during phage T4 sheath contraction, GDP remains bound to the sheath protein (gp18), whereas orthophosphate is released. gp18 in the contracted state has GTPase activity and can hydrolyse exogenous GTP; the reaction is calcium-dependent and displays high substrate specificity ...
I I, Serysheva, A I, Tourkin, I V, Bartish, B F, Poglazov   +3 more
openaire   +2 more sources