Results 311 to 320 of about 958,866 (334)

Rho GTPase-activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases

Molecular and Cellular Neuroscience, 2017
The Rho family of small GTPases was considered as molecular switches in regulating multiple cellular events, including cytoskeleton reorganization. The Rho GTPase-activating proteins (RhoGAPs) are one of the major families of Rho GTPase regulators.
Dong-Fu Feng, Zhao-Liang Sun, Hong-Jiang Li, Guo-Hui Huang   +3 more
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Rho GTPase Activating Proteins in Cancer Phenotypes

Current Protein & Peptide Science, 2006
Rho proteins belong to the Ras superfamily of small GTPases and function as binary switches that shuttle between active and inactive states based on the nature of bound guanine nucleotide. Three sets of regulatory proteins, namely, guanine dissociation inhibitors, guanine exchange factors, and GTPase activating proteins (GAPs) control the balance ...
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[8] Purification and properties of Rab3 GTPase-activating protein

2001
This chapter describes the assays for the Rab3 guanosine-5'-triphosphate (GTP)ase-activating proteins (GAP) activity, the procedures for the purification of native Rab3 GAP from rat brain synaptic soluble fraction, the procedures for the purification of recombinant hexahistidine (His6)-tagged Rab3 GAP from Escherichia coli, and the properties of Rab3
Takuya Sasaki, Yoshimi Takai, Fumiko Nagano   +2 more
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Inhibition and Termination of Physiological Responses by GTPase Activating Proteins

Physiological Reviews, 2012
Physiological processes are strictly organized in space and time. However, in cell physiology research, more attention is given to the question of space rather than to time. To function as a signal, environmental changes must be restricted in time; they need not only be initiated but also terminated.
Stefan Welti, Erzsébet Ligeti, Klaus Scheffzek   +2 more
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PDGF induction of tyrosine phosphorylation of GTPase activating protein [PDF]

Nature, 1989
The cascade of biochemical events triggered by growth factors and their receptors is central to understanding normal cell-growth regulation and its subversion in cancer. Ras proteins (p21ras) have been implicated in signal transduction pathways used by several growth factors, including platelet-derived growth factor (PDGF).
Stuart A. Aaronson, Jackson B. Gibbs, Christopher J. Molloy, Timothy P. Fleming, Donald P. Bottaro, Mark S. Marshall   +5 more
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Changing expression of GTPase activating proteins with differentiation in neuroblastoma

Journal of the Neurological Sciences, 1994
p21ras is a membrane-associated guanine nucleotide-binding protein with intrinsic GTPase activity. Like other guanine nucleotide-binding proteins p21ras is active when GTP bound and inactive when GDP bound. Phosphorylation of p21ras is regulated by the GTPase activity of type I GAP120 and NF1-GRD.
P.A. Berry, S.A. Burchill, I.J. Lewis
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AGD5 is a GTPase-activating protein at the trans-Golgi network

The Plant Journal, 2010
ARF-GTPases are important proteins that control membrane trafficking events. Their activity is largely influenced by the interplay between guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which facilitate the activation or inactivation of ARF-GTPases, respectively. There are 15 predicted proteins that contain an ARF-GAP
Stefano G., Renna L., Rossi M., AZZARELLO, ELISA, POLLASTRI, SUSANNA, Brandizzi F., Baluska F., MANCUSO, STEFANO   +7 more
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The GTPase-activating protein Rap1GAP uses a catalytic asparagine

Nature, 2004
Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by guanine-nucleotide-exchange factors (GEFs) and GTPase-activating proteins ...
Ingrid R. Vetter, Partha Pratim Chakrabarti, Michael Weyand, Oliver Daumke, Alfred Wittinghofer   +4 more
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Bacterial mimics of eukaryotic GTPase-activating proteins (GAPs)

Trends in Biochemical Sciences, 2003
Bacterial GTPase-activating proteins (GAPs) subvert their host's eukaryotic Rho GTPases to their own advantage. Studies of bacterial GAPs extend our understanding of the action of eukaryotic GAPs, provide new tools for studies of cytoskeletal dynamics and offer new targets for anti-bacterial drugs.
Zvi Selinger, Yael Litvak
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Regulation of the GTPase activity of the ras-related rap2 protein

Biochemical and Biophysical Research Communications, 1992
The small GTP-binding protein rap2A exhibits a high level of identity with rap1 and ras proteins (60% and 46%, respectively). Nevertheless, its intrinsic GTPase activity is not stimulated by ras-GAP, and unlike the rap1A protein, it cannot compete with ras proteins for their interaction with ras-GAP.
Isabelle Janoueix-Lerosey, Jean de Gunzburg, Armand Tavitian, Paul G. Polakis   +3 more
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