Results 31 to 40 of about 958,866 (334)
Characterization of the Rho GTPase-Activating Protein RhoGAP68F
Experimental Neurobiology, 2011 Rho small GTPases control multiple aspects of neuronal morphogenesis by regulating the assembly and organization of the actin cytoskeleton. Although they are negatively regulated by GTPase activating proteins (GAPs), the roles of RhoGAPs in the nervous system have not been fully investigated.
Minyeop Nahm, Seungbok Lee
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A serine/threonine protein kinase encoding gene KERNEL NUMBER PER ROW6 regulates maize grain yield
Nature Communications, 2020 Selection of kernel number per ear has improved maize yield, but the genetic base is unclear. Here, the authors reveal that a serine/threonine protein kinase KNR6 is a positive regulator of the trait and show in vitro evidences that KNR6 may function ...
Haitao Jia +12 more
doaj +1 more source
Biochemical Journal, 2005 Recently, we described a 160 kDa protein (designated AS160, for Akt substrate of 160 kDa) with a predicted Rab GAP (GTPase-activating protein) domain that is phosphorylated on multiple sites by the protein kinase Akt.
C. Mîinea +7 more
semanticscholar +1 more source
Cells, 2020 The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-activating ...
Daji Guo, Xiaoman Yang, Lei Shi
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Proteasomal turnover of the RhoGAP tumor suppressor DLC1 is regulated by HECTD1 and USP7
Scientific Reports, 2022 The Rho GTPase activating protein Deleted in Liver Cancer 1 (DLC1) is frequently downregulated through genetic and epigenetic mechanisms in various malignancies, leading to aberrant Rho GTPase signaling and thus facilitating cancer progression.
Yannick Frey +3 more
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Expression of human G3BP1 in E. coli [PDF]
E3S Web of Conferences, 2021 G3BP1 (Ras-GTPase-activating protein SH3 domain-binding protein) is responsible for normal RNA stress granule (SG) assembly and overexpressed in many cancer cells. Deletion of G3BP1 decreases the number and size of SGs.
Yang Ziwei
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Journal of Biological Chemistry, 2005 Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular vesicles to the plasma membrane. In the present study we have conducted a comprehensive proteomic analysis of affinity-purified GLUT4 vesicles from 3T3-L1 adipocytes
Mark Larance +10 more
semanticscholar +1 more source
Protein Translocation: Checkpoint Role for SRP GTPase Activation [PDF]
Current Biology, 2007 Co-translational protein targeting by the signal recognition particle (SRP) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site.
Gert Bange +2 more
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Cells, 2021 Age-related macular degeneration (AMD) is one of the leading causes of blindness worldwide. Vision loss from the neovascular form is associated with the invasion of choroidal endothelial cells into the neural retina to form vision-threatening macular ...
Aniket Ramshekar +2 more
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RUTBC2 Protein, a Rab9A Effector and GTPase-activating Protein for Rab36 [PDF]
Journal of Biological Chemistry, 2012 Rab GTPases regulate vesicle budding, motility, docking, and fusion. In cells, their cycling between active, GTP-bound states and inactive, GDP-bound states is regulated by the action of opposing enzymes called guanine nucleotide exchange factors and GTPase-activating proteins (GAPs).
Nottingham, Ryan M. +5 more
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