Results 41 to 50 of about 958,866 (334)
eLife, 2017 The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium ...
Bo Gong +5 more
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Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum. [PDF]
PLoS ONE, 2013 DOC-2/DAB-2 interacting protein (Dab2IP) is a GTPase activating protein that binds to Disabled-1, a cytosolic adapter protein involved in Reelin signaling and brain development.
Shuhong Qiao +5 more
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Journal of Cell Biology, 1998 RanGAP1 is the GTPase-activating protein for Ran, a small ras-like GTPase involved in regulating nucleocytoplasmic transport. In vertebrates, RanGAP1 is present in two forms: one that is cytoplasmic, and another that is concentrated at the cytoplasmic ...
M. Matunis, Jian Wu, G. Blobel
semanticscholar +1 more source
This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
Frontiers in Cell and Developmental Biology, 2018 Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission.
Christopher Stroupe
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The Ras GTPase-activating protein Rasal3 supports survival of naive T cells. [PDF]
PLoS ONE, 2015 The Ras-mitogen-activated protein kinase (MAPK) pathway is crucial for T cell receptor (TCR) signaling in the development and function of T cells. The significance of various modulators of the Ras-MAPK pathway in T cells, however, remains to be fully ...
Ryunosuke Muro +5 more
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Functional Role of AGAP2/PIKE-A in Fcγ Receptor-Mediated Phagocytosis
Cells, 2022 In phagocytes, cytoskeletal and membrane remodeling is finely regulated at the phagocytic cup. Various smaFll G proteins, including those of the Arf family, control these dynamic processes.
François C. Chouinard +3 more
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Regulation of ras p21 by GTPase Activating Proteins
Cold Spring Harbor Symposia on Quantitative Biology, 1991 We propose a model for dual effector functions of the known ras GAPs p120-GAP and NF1-GAP. This model is consistent with known biological and biochemical effects of GAPs in mammalian cells, but it is clearly not a proven hypothesis, and several difficulties remain in making this model convincing.
F McCormick +4 more
openaire +3 more sources
RACGAP1 (Rac GTPase activating protein 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review on RACGAP1, with data on DNA, on the protein encoded, and where the gene is ...
Strimpakos, Alexios +2 more
openaire +2 more sources
Roles of Rap1 signaling in tumor cell migration and invasion
Cancer Biology & Medicine, 2017 Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang +4 more
doaj +1 more source
Rho GTPase-Activating Protein 32
Definitions, 2020 Rho GTPase-activating protein 32 (2087 aa, ~231 kDa) is encoded by the human ARHGAP32 gene. This protein is involved in the regulation of signaling mediated by both Rho family GTPases and the NMDA receptor.
semanticscholar +1 more source