Results 51 to 60 of about 958,866 (334)
The yeast Rgd1p is a GTPase activating protein of the Rho3 and Rho4 proteins [PDF]
FEBS Letters, 1999 The RGD1 gene, identified during sequencing of the Saccharomyces cerevisiae genome, encodes a protein with a Rho‐GTPase activating protein (GAP) domain at the carboxy‐terminal end. The Rgd1 protein showed two‐hybrid interactions with the activated forms of Rho2p, Rho3p and Rho4p.
Olivier Roumanie +3 more
openaire +3 more sources
Spatiotemporal Regulation of Rho GTPases in Neuronal Migration
Cells, 2019 Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar−bipolar transition, locomotion, and translocation.
Zhenyan Xu, Yuewen Chen, Yu Chen
doaj +1 more source
Identification of a GTPase-Activating Protein Homolog in Schizosaccharomyces pombe [PDF]
Molecular and Cellular Biology, 1991 Loss of function of the Schizosaccharomyces pombe gap1 gene results in the same phenotypes as those caused by an activated ras1 mutation, i.e., hypersensitivity to the mating factor and inability to perform efficient mating. Sequence analysis of gap1 indicates that it encodes a homolog of the mammalian Ras GTPase-activating protein (GAP). The predicted
Imai, Yoshiyuki +3 more
openaire +4 more sources
Bioinformatics Analysis of Rho GTP-ase Activating Protein 35 (ARHGAP35) in Breast Cancer Migration
ISCC (Indonesian Journal of Cancer Chemoprevention), 2021 Breast cancer is a second deadly cancer after lung cancer worldwide. Progression of cancer is driven by mutated cancer drive gene such as ARHGAP35. This study aims to analyze the role of ARHGAP35 in the growth and development of breast cancer cells ...
Dicky Rizky Febrian +5 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
RASAL2 Plays Inconsistent Roles in Different Cancers
Frontiers in Oncology, 2019 RAS protein activator like 2 (RASAL2) belongs to the RAS GTPase-activating protein family and plays an important role in several cancers, including ovarian cancer, nasopharyngeal carcinoma, malignant astrocytoma, renal cell carcinoma, bladder cancer ...
Bolun Zhou +3 more
doaj +1 more source
Journal of Biological Chemistry, 2004 Endosomal Na+/H+ exchangers are important for salt and osmotolerance, vacuolar pH regulation, and endosomal trafficking. We show that the C terminus of yeast Nhx1 interacts with Gyp6, a GTPase-activating protein for the Ypt/Rab family of GTPases, and ...
R. Ali +3 more
semanticscholar +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Nature Communications, 2018 Chronic myelogenous leukemia (CML)-initiating cells are resistant to kinase inhibitors. Here the authors show that deficiency of the Rap1 GTPase-activating protein Sipa1 in the tumor microenvironment releases an immune response that eradicates CML ...
Yan Xu +5 more
doaj +1 more source
GTP Binding Assays in Arabidopsis thaliana
Bio-Protocol, 2013 Signaling through G proteins constitutes an ancient mechanism that functions in the transduction of extracellular signals into intracellular responses. Activation of a proper receptor by a stimuli leads to an exchange of GDP for GTP, the activation of G ...
Ana Fox, Maria Mazzella
doaj +1 more source