Results 51 to 60 of about 137,270 (354)

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]

, 2017
Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S., Blanco, Francisco J., Blanco-Canosa, Juan B., Cerione, Richard A., de la Cruz-Morcillo, Miguel Angel, DiGiacomo, Vincent, Garcia-Marcos, Mikel, Ibáñez de Opakua, Alain, Leyme, Anthony, Marivin, Arthur, Merino, Nekane, Nguyen, Lien T., Parag-Sharma, Kshitij, Ramachandran, Sekar, Villate, Maider   +14 more
core   +1 more source

DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. [PDF]

, 2010
Deleted in liver cancer 1 (DLC1) is a RhoGTPase activation protein-containing tumor suppressor that associates with various types of cancer. Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized.
Chen, N-T, Liao, Y-C, Lin, Y, Lo, SH, Shih, Y-P, Xue, L   +5 more
core   +3 more sources

Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]

, 1999
RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S., Caron, Joan M., Chen, Ching-Kang, Druey, Kirk M., Jones, Teresa L. Z., Ugur, Ozlem   +5 more
core   +1 more source

Spatiotemporal Regulation of Rho GTPases in Neuronal Migration

Cells, 2019
Neuronal migration is essential for the orchestration of brain development and involves several contiguous steps: interkinetic nuclear movement (INM), multipolar−bipolar transition, locomotion, and translocation.
Zhenyan Xu, Yuewen Chen, Yu Chen
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

RASAL2 Plays Inconsistent Roles in Different Cancers

Frontiers in Oncology, 2019
RAS protein activator like 2 (RASAL2) belongs to the RAS GTPase-activating protein family and plays an important role in several cancers, including ovarian cancer, nasopharyngeal carcinoma, malignant astrocytoma, renal cell carcinoma, bladder cancer ...
Bolun Zhou, Wei Zhu, Xingjun Jiang, Caiping Ren   +3 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]

, 2008
© 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Ammerer G., Andoh T., Bose I., Bosl W. J., Bourmeyster N., Christopher Tiedje, Chuang T. H., Cole K. C., Daniel Lew, DerMardirossian C., DerMardirossian C., Dovas A., Dransart E., Eitzen G., Forget M. A., Gladfelter A. S., Gulli M. P., Hoffman G. R., Höfken T., Höfken T., Imme Sakwa, Irazoqui J. E., Irazoqui J. E., Jaffe A. B., Janke C., Jensen S., Kassir Y., Kim L., Knop M., Koch G., Lee D. H., Longtine M. S., Marco E., Masuda T., Mazón M. J., Mehta D., Mösch H. U., Nomanbhoy T. K., Palecek S. P., Park H. O., Ptacek J., Richman T. J., Richman T. J., Roberts R. L., Roth A. F., Rotin D., Scheffzek K., Schwamborn J. C., Seshan A., Takahashi K., Tcheperegine S. E., Thomas Höfken, Ursula Just, Valdez-Taubas J., Wang H. R., Wedlich-Soldner R., Yamashita T., Yamochi W., Ziman M.   +58 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells

Nature Communications, 2018
Chronic myelogenous leukemia (CML)-initiating cells are resistant to kinase inhibitors. Here the authors show that deficiency of the Rap1 GTPase-activating protein Sipa1 in the tumor microenvironment releases an immune response that eradicates CML ...
Yan Xu, Satoshi Ikeda, Kentaro Sumida, Ryusuke Yamamoto, Hiroki Tanaka, Nagahiro Minato   +5 more
doaj   +1 more source