Results 81 to 90 of about 958,866 (334)

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A‐Mediated Endolysosomal Trafficking and Degradation of EGFR

Advanced Science
Hepatocellular carcinomas (HCCs) are characterized by a vast spectrum of somatic copy number alterations (CNAs); however, their functional relevance is largely unknown.
Pengbo Cao, Hongxia Chen, Ying Zhang, Qi Zhang, Mengting Shi, Huihui Han, Xiaowen Wang, Liang Jin, Bingqian Guo, Rongjiao Hao, Xi Zhao, Yuanfeng Li, Chengming Gao, Xinyi Liu, Yahui Wang, Aiqing Yang, Chenning Yang, Anfeng Si, Hua Li, Qingfeng Song, Fuchu He, Gangqiao Zhou   +21 more
doaj   +1 more source

G3BP1 modulates SPOP to promote prostate tumorigenesis

Molecular & Cellular Oncology, 2022
Speckle-type POZ protein (SPOP), a Cullin 3-based ubiquitin ligase (CUL3SPOP), acts as a prostate-specific tumor suppressor. Loss-of-function mutations in SPOP occur in 10% of primary prostate cancer with a high Gleason grade and poor prognosis. However,
Chandrani Mukhopadhyay, Pengbo Zhou
doaj   +1 more source

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

Proceedings of the National Academy of Sciences of the United States of America, 1998
G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation.
R. Premont, A. Claing, Nicolas Vitale, J. L. Freeman, J. Pitcher, Walter A. Patton, Joel Moss, Martha Vaughan, R. Lefkowitz   +8 more
semanticscholar   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

ARHGAP20 (Rho GTPase activating protein 20) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on ARHGAP20 (Rho GTPase activating protein 20), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

ARHGAP21 (Rho GTPase activating protein 21) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
ARHGAP21 is a Rho GTPase-activating protein (RhoGAP). Like other members of the RhoGAP family, ARHGAP21 enhances the intrinsic GTPase activity of small Rho GTPases, leading to their inactivation. ARHGAP21 participates in cellular proliferation, adhesion, migration and vesicle traffic.
Ferreira Pissarra, Mariana, Olalla Saad, Sara Teresinha, Lazarini, Mariana   +2 more
openaire   +2 more sources

Engineered MSC Aggregates with E/N‐Cadherin and IL‐6 Preconditioning for the Treatment of Systemic Sclerosis

Advanced Healthcare Materials, EarlyView.
Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang, Mengyuan Qian, Yirui Shi, Jiaxu Cao, Min Xu, Xin Wen, Yunxia Yan, Sha Liu, Hongwei Chen, Shanshan Liu, Jun Yang, Lingyun Sun   +11 more
wiley   +1 more source

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

eLife, 2020
Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult ...
Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman   +10 more
doaj   +1 more source

Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole

Molecular Biology of the Cell, 2015
Endocytic transport depends on two consecutive Rabs, Vps21 (Rab5 in metazoans) and Ypt7 (Rab7), which bind to effectors on early and late endosomes. This study now shows that inactivation of Vps21 via its GTPase-activating protein (GAP) Msb3 requires ...
M. Rana, Jens Lachmann, C. Ungermann
semanticscholar   +1 more source