The roles of GTPase-activating proteins in regulated cell death and tumor immunity [PDF]
Journal of Hematology & Oncology, 2021 GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form.
Hua He +10 more
doaj +3 more sources
Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma [PDF]
Frontiers in Oncology, 2022 IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction.
Qingqing Dai +5 more
doaj +2 more sources
Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions. [PDF]
Cold Spring Harb Perspect Med, 2019 Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition state stabilizing mechanism. Oncogenic Ras is commonly not sensitive
Scheffzek K, Shivalingaiah G.
europepmc +2 more sources
Regulation of VEGFR2 trafficking and signaling by Rab GTPase-activating proteins. [PDF]
Sci Rep, 2019 Vascular endothelial growth factor receptor-2 (VEGFR2) and its ligands (VEGFs) are crucial players in vasculogenesis and angiogenesis. General blocking of this signaling system with antibodies or small molecule inhibitors is an established strategy to ...
Xie Y, Mansouri M, Rizk A, Berger P.
europepmc +2 more sources
Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4 [PDF]
Frontiers in Neuroscience, 2022 The cerebral cortex comprises a complex and exquisite network of neuronal circuits that is formed during development. To explore the molecular mechanisms involved in cortical circuit formation, the tactile somatosensory pathway that connects the whiskers
Madhura S. Rao +7 more
doaj +2 more sources
Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers. [PDF]
Cancer Res, 2016 The basal-like breast cancer (BLBC) subtype accounts for a disproportionately high percentage of overall breast cancer mortality. The current therapeutic options for BLBC need improvement; hence, elucidating signaling pathways that drive BLBC growth may ...
Lawson CD +9 more
europepmc +2 more sources
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]
Journal of Cell Biology, 2007 Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Barr, Francis A. +5 more
core +3 more sources
Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast. [PDF]
J Cell Sci, 2019 The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments.
Arakel EC +5 more
europepmc +2 more sources
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins. [PDF]
Nat Commun, 2015 Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires ...
Schlam D +6 more
europepmc +2 more sources
GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6 [PDF]
Journal of Biological Chemistry, 2000 ADP-ribosylation factor (ARF) proteins are key players in numerous vesicular trafficking events ranging from the formation and fusion of vesicles in the Golgi apparatus to exocytosis and endocytosis. To complete their GTPase cycle, ARFs require a guanine
Nicolas Vitale +5 more
openalex +2 more sources