Results 1 to 10 of about 129,543 (335)

In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia [PDF]

Journal of Genetic Engineering and Biotechnology
Giardia lamblia is a globally prevalent protozoan responsible for Giardiasis, an intestinal disease commonly treated with nitroimidazoles such as metronidazole, tinidazole, and albendazole.
Nurhana Jasni, Khairul Bariyyah Abd. Halim, Wong Weng Kin, Darren Lau, Clifford Young, Peter Hoffmann, Nurulhasanah Othman   +6 more
doaj   +3 more sources

Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma [PDF]

Frontiers in Oncology, 2022
IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction.
Qingqing Dai, Qingqing Dai, Quratul Ain, Michael Rooney, Fei Song, Alexander Zipprich   +5 more
doaj   +2 more sources

The roles of GTPase-activating proteins in regulated cell death and tumor immunity [PDF]

Journal of Hematology & Oncology, 2021
GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form.
Hua He, Jingjing Huang, Sufang Wu, Shiyao Jiang, Lu Liang, Yueying Liu, Wenbing Liu, Li Xie, Yongguang Tao, Yiqun Jiang, Li Cong   +10 more
doaj   +2 more sources

Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4 [PDF]

Frontiers in Neuroscience, 2022
The cerebral cortex comprises a complex and exquisite network of neuronal circuits that is formed during development. To explore the molecular mechanisms involved in cortical circuit formation, the tactile somatosensory pathway that connects the whiskers
Madhura S. Rao, Madhura S. Rao, Hiromi Mizuno, Hiromi Mizuno, Takuji Iwasato, Takuji Iwasato, Hidenobu Mizuno, Hidenobu Mizuno   +7 more
doaj   +2 more sources

Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II [PDF]

, 2004
synGAP is a neuron-specific Ras GTPase-activating protein found in high concentration in the postsynaptic density fraction from mammalian forebrain. Proteins in the postsynaptic density, including synGAP, are part of a signaling complex attached to the ...
Kennedy, Mary B., Manzerra, Pasquale, Oh, Jeong S.   +2 more
core   +3 more sources

Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast. [PDF]

J Cell Sci, 2019
The Arf GTPase controls formation of the COPI vesicle coat. Recent structural models of COPI revealed the positioning of two Arf1 molecules in contrasting molecular environments.
Arakel EC, Huranova M, Estrada AF, Rau EM, Spang A, Schwappach B.   +5 more
europepmc   +2 more sources

Cdc42 GTPase-activating proteins (GAPs) regulate generational inheritance of cell polarity and cell shape in fission yeast. [PDF]

Mol Biol Cell, 2021
Pino MR, Nuñez I, Chen C, Das ME, Wiley DJ, D'Urso G, Buchwald P, Vavylonis D, Verde F.   +8 more
europepmc   +3 more sources

Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions. [PDF]

Cold Spring Harb Perspect Med, 2019
Scheffzek K, Shivalingaiah G.
europepmc   +3 more sources

Arf GTPase-Activating proteins ADAP1 and ARAP1 regulate incorporation of CD63 in multivesicular bodies [PDF]

Biology Open
Kasumi Suzuki, Yoshitaka Okawa, Sharmin Akter, Haruki Ito, Yoko Shiba   +4 more
doaj   +2 more sources

Fixing the GAP: The role of RhoGAPs in cancer

European Journal of Cell Biology, 2022
Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins.
Gabriel Kreider-Letterman, Nicole M. Carr, Rafael Garcia-Mata   +2 more
doaj   +1 more source