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GTPase-activating proteins and their complexes
Current Opinion in Structural Biology, 1998In the past year, crystallographic structures for four complexes of GTPase-activating proteins (GAPs) with their target G proteins have been described and substantially enhance our understanding of how these proteins function. GAPs specific for the Rho and Ras families of small G proteins insert an arginine residue into the active site of the G protein,
Stephen J. Smerdon, Steven J. Gamblin
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1993
Since Ras proteins negotiate many signalling pathways leading to cell growth or differentiation, the regulation of Ras activity is vital to cellular health. Ras activity, which derives from a collaboration between Ras and GTP, is terminated by the GTPase activating protein (GAP)-catalyzed hydrolysis of the GTP. Hence, a simple regulatory scheme emerges:
G Bollag, F McCormick
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Since Ras proteins negotiate many signalling pathways leading to cell growth or differentiation, the regulation of Ras activity is vital to cellular health. Ras activity, which derives from a collaboration between Ras and GTP, is terminated by the GTPase activating protein (GAP)-catalyzed hydrolysis of the GTP. Hence, a simple regulatory scheme emerges:
G Bollag, F McCormick
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Ras interaction with the GTPase‐activating protein (GAP)
Proteins: Structure, Function, and Bioinformatics, 1989AbstractBiologically active forms of Ras complexed to GTP can bind to the GTP ase‐activating protein (GAP), which has been implicated as a possible target of Ras in mammalian cells. In order to study the structural features of Ras required for this interaction, we have evaluated a series of mutant ras proteins for the ability to bind GAP and a series ...
Douglas Boylan +7 more
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GTPase activity of bacteriophage T4 sheath protein
Journal of Molecular Biology, 1992We show by nuclear magnetic resonance studies that, following GTP hydrolysis during phage T4 sheath contraction, GDP remains bound to the sheath protein (gp18), whereas orthophosphate is released. gp18 in the contracted state has GTPase activity and can hydrolyse exogenous GTP; the reaction is calcium-dependent and displays high substrate specificity ...
I. V. Bartish +3 more
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ARF GTPase-Activating Protein 1
2003Regulators of Arf activity include a family of proteins with a shared domain, the cysteine-rich Arf GAP domain, that is responsible for activating the latent GTPase activity of Arfs. The first of these to be discovered, Arf GAP1 is the focus of this chapter.
Irit Huber +3 more
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Rho GTPase-Activating Proteins in Cancer [PDF]
, 2009 Rho GTPases are involved in a variety of cellular functions and require strict regulation to insure proper signaling. As negative regulators of the Rho proteins, Rho GTPase-activating proteins (GAPs) also play critical roles in cytoskeleton regulation, cell-cycle control, gene expression, and normal development.
Matthew W. Grogg, Yi Zheng
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Bcr encodes a GTPase-activating protein for p21rac
Nature, 1991More than thirty small guanine nucleotide-binding proteins related to the ras-encoded oncoprotein, termed Ras or p21ras, are known. They regulate many fundamental processes in all eukaryotic cells, such as growth, vesicle traffic and cytoskeletal organization.
Michelle D. Garrett +8 more
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Molecular and Cellular Neuroscience, 2017
The Rho family of small GTPases was considered as molecular switches in regulating multiple cellular events, including cytoskeleton reorganization. The Rho GTPase-activating proteins (RhoGAPs) are one of the major families of Rho GTPase regulators.
Dong-Fu Feng +3 more
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The Rho family of small GTPases was considered as molecular switches in regulating multiple cellular events, including cytoskeleton reorganization. The Rho GTPase-activating proteins (RhoGAPs) are one of the major families of Rho GTPase regulators.
Dong-Fu Feng +3 more
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Rho GTPase Activating Proteins in Cancer Phenotypes
Current Protein & Peptide Science, 2006Rho proteins belong to the Ras superfamily of small GTPases and function as binary switches that shuttle between active and inactive states based on the nature of bound guanine nucleotide. Three sets of regulatory proteins, namely, guanine dissociation inhibitors, guanine exchange factors, and GTPase activating proteins (GAPs) control the balance ...
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[8] Purification and properties of Rab3 GTPase-activating protein
2001This chapter describes the assays for the Rab3 guanosine-5'-triphosphate (GTP)ase-activating proteins (GAP) activity, the procedures for the purification of native Rab3 GAP from rat brain synaptic soluble fraction, the procedures for the purification of recombinant hexahistidine (His6)-tagged Rab3 GAP from Escherichia coli, and the properties of Rab3
Takuya Sasaki +2 more
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