Results 41 to 50 of about 13,809 (125)
MEGADOCK-Web-Mito: human mitochondrial protein-protein interaction prediction database [PDF]
arXiv, 2021 Mitochondrial diseases are largely caused by dysfunction in mitochondrial proteins. However, annotations of human mitochondrial proteins are scattered across various public databases and individual studies. To facilitate research aimed at elucidating mitochondrial functions, we constructed the MEGADOCK-Web-Mito database as a protein-protein interaction
arxiv
Molecular mechanisms of Sar/Arf GTPases in vesicular trafficking in yeast and plants
Frontiers in Plant Science, 2014 Small GTPase proteins play essential roles in the regulation of vesicular trafficking systems in eukaryotic cells. Two types of small GTPases, secretion-associated Ras-related protein (Sar) and ADP-ribosylation factor (Arf), act in the biogenesis of ...
Tomohiro eYorimitsu +2 more
doaj +1 more source
Knowledge-based energy functions for computational studies of proteins [PDF]
, 2006 This chapter discusses theoretical framework and methods for developing knowledge-based potential functions essential for protein structure prediction, protein-protein interaction, and protein sequence design. We discuss in some details about the Miyazawa-Jernigan contact statistical potential, distance-dependent statistical potentials, as well as ...
arxiv +1 more source
Small antimicrobial resistance proteins (SARPs): Small proteins conferring antimicrobial resistance [PDF]
arXiv, 2023 Small open reading frames are understudied as they have been historically excluded from genome annotations. However, evidence for the functional significance of small proteins in various cellular processes accumulates. Proteins with less than 70 residues can also confer resistance to antimicrobial compounds, including intracellularly-acting protein ...
arxiv
β2-Chimaerin Deficiency Favors Polyp Growth in the Colon of ApcMin/+ Mice
MoleculesA Rho-GTPases are pivotal regulators of key cellular processes implicated in colorectal cancer (CRC) progression, yet the roles of their regulatory proteins, particularly GTPase-activating proteins (GAPs), remain poorly understood.
Eladio A. Velasco-Sampedro +2 more
doaj +1 more source
Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences [PDF]
PNAS 103, 11527- 11532 (2006); Aug 1, 2006 no 31, 2006 Major advances in large-scale yeast two hybrid (Y2H) screening have provided a global view of binary protein-protein interactions across species as dissimilar as human, yeast, and bacteria. Remarkably, these analyses have revealed that all species studied have a degree distribution of protein-protein binding that is approximately scale-free (varies as ...
arxiv +1 more source
eLife, 2017 The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium ...
Bo Gong +5 more
doaj +1 more source
Protein Inference and Protein Quantification: Two Sides of the Same Coin [PDF]
arXiv, 2012 Motivation: In mass spectrometry-based shotgun proteomics, protein quantification and protein identification are two major computational problems. To quantify the protein abundance, a list of proteins must be firstly inferred from the sample. Then the relative or absolute protein abundance is estimated with quantification methods, such as spectral ...
arxiv
Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks? [PDF]
arXiv, 2006 In protein-protein interaction networks certain topological properties appear to be recurrent: networks maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper we investigate the role of protein disorder in the network topology.
arxiv
Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation
Biology Open, 2016 The Deleted in liver cancer 1 (Dlc1) gene codes for a Rho GTPase-activating protein that also acts as a tumour suppressor gene. Several studies have consistently found that overexpression leads to excessive cell elongation, cytoskeleton changes and ...
Mohammad G. Sabbir +2 more
doaj +1 more source