Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C
Journal of Cell Biology, 2010 A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.
Chieh Hsu +11 more
semanticscholar +1 more source
mBio, 2014 Pseudomonas aeruginosa is a Gram-negative pathogen commonly associated with nosocomial infections such as hospital-acquired pneumonia. It uses a type III secretion system to deliver effector proteins directly into the cytosol of host cells.
Stephanie M. Rangel +2 more
doaj +1 more source
Phosphoproteome Profiling of SH-SY5y Neuroblastoma Cells Treated with Anesthetics: Sevoflurane and Isoflurane Affect the Phosphorylation of Proteins Involved in Cytoskeletal Regulation. [PDF]
PLoS ONE, 2016 Inhalation anesthetics are used to decrease the spinal cord transmission of painful stimuli. However, the molecular or biochemical processes within cells that regulate anesthetic-induced responses at the cellular level are largely unknown.
Joomin Lee +3 more
doaj +1 more source
GAP activity, but not subcellular targeting, is required for Arabidopsis RanGAP cellular and developmental functions [PDF]
, 2015 The Ran GTPase activating protein (RanGAP) is important to Ran signaling involved in nucleocytoplasmic transport, spindle organization, and postmitotic nuclear assembly.
Boruc, Joanna +6 more
core +2 more sources
Protein Translocation: Checkpoint Role for SRP GTPase Activation [PDF]
Current Biology, 2007 Co-translational protein targeting by the signal recognition particle (SRP) relies on a complex series of structural rearrangements in the SRP and its receptor (SR). In order to precisely coordinate the individual steps, the GTPases of the SRP and the SR form a unique complex in which GTP hydrolysis is activated in a composite active site.
Gert Bange +2 more
openaire +3 more sources
Rab11 and Its Role in Neurodegenerative Diseases
ASN Neuro, 2022 Vesicles mediate the trafficking of membranes/proteins in the endocytic and secretory pathways. These pathways are regulated by small GTPases of the Rab family.
Pinky Sultana, Jiri Novotny
doaj +1 more source
Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]
, 1999 RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S. +5 more
core +1 more source
RUTBC2 Protein, a Rab9A Effector and GTPase-activating Protein for Rab36 [PDF]
Journal of Biological Chemistry, 2012 Rab GTPases regulate vesicle budding, motility, docking, and fusion. In cells, their cycling between active, GTP-bound states and inactive, GDP-bound states is regulated by the action of opposing enzymes called guanine nucleotide exchange factors and GTPase-activating proteins (GAPs).
Nottingham, Ryan M. +5 more
openaire +4 more sources
Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants [PDF]
, 2009 ACAP-type ARF GTPase activating proteins (ARF-GAPs) regulate multiple cellular processes, including endocytosis, secretion, phagocytosis, cell adhesion and cell migration.
Friml, Jiri +6 more
core +1 more source
Current opinion in hematology, 2016 Purpose of reviewThe review describes the roles of Rho- and Rap-guanosine triphosphatases (GTPases) and of their activators, guanine-nucleotide exchange factors (GEFs), and inhibitors, GTPase activating proteins (GAPs), in neutrophil recruitment from the
Martin J. Baker +2 more
semanticscholar +1 more source