Results 131 to 140 of about 188,398 (263)
GTPase-activating properties of ARHGAP11A.
, 2013 (A) Halo-Tagged ARHGAP11A and Halo-Tag proteins expressed and purified from HEK293 cells. (B) Detection of GTPase activity by quantifying inorganic phosphate released by GTP hydrolysis by Rho family proteins.
Yuji Kamioka (503601) +24 more
core +1 more source
Advanced Science, EarlyView.A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa +6 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Homeoprotein Hbx4 represses adhesion molecule governing cytokinesis and development [PDF]
, 2010 Homeobox genes encode proteins with a highly conserved DNA-binding motif and provoke morphological diversification of body segments by differentially controlling the expression of downstream targets.
Ji-Sun Kim +3 more
core
GTPase activity and Cc of FtsZ mutants.
, 2013 GTPase activity and Cc of FtsZ mutants.
Jefferson Bettini (399781) +7 more
core +1 more source
Advanced Science, EarlyView.The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu +4 more
wiley +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
Wiring the developing brain: The Rho GTPase signaling network in neurodevelopmental disorders
Neurobiology of DiseaseHuman genetics has substantially advanced our understanding of the Rho GTPase signaling network in brain development and established its dysregulation as an important mechanism underlying neurodevelopmental disorders (NDDs).
Antonio Falace +8 more
doaj +1 more source
Mitotic Control by Ran and RanBP1 in Mammalian Cells
, 2001 This chapter is an invited contribution to the book "The Small GTPase Ran", and describes the emerging roles of the RAN GTPase network, a signalling network implicated in many cellular functions, during cell division in human ...
Giulia Guarguaglini +2 more
core