Results 111 to 120 of about 188,398 (263)
Advanced Science, EarlyView.Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu +12 more
wiley +1 more source
Advanced Science, EarlyView.Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu +4 more
wiley +1 more source
GTPase-deficient MX2 has distinct nucleoporin requirements for antiviral activity.
A) Schematic representation of the nuclear pore complex and genes included in siRNA library color coded by subcomplex. (*- NUP98 is listed as a member of Nup107 subcomplex, however.
Bailey Layish (18196714) +6 more
core +1 more source
ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites
Advanced Science, EarlyView.ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng +9 more
wiley +1 more source
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
Nature Communications, 2016 Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia +13 more
doaj +1 more source
Down-Regulated Expression of Rhoa in Human Conventional Renal Cell Carcinoma
, 2009 Background: Renal cell carcinoma (RCC) is the most common cancer in adult kidney. Delayed diagnosis may result in progression and metastasis. Markers for early detection of RCC are lacking.
蒲永孝;王壯維;劉光耀;郭怡孜;黃昭淵;孫家棟;林家齊;吳文正;侯自銓 +1 more
core
Advanced Science, EarlyView.TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu +9 more
wiley +1 more source
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Nature Communications, 2019 Deregulation of the RAS GTPase cycle due to mutations in RAS genes is commonly associated with cancer development. Here authors use NMR and mass spectrometry to shows that KRAS phosphorylation via Src alters the conformation of switch I and II regions ...
Yoshihito Kano +18 more
doaj +1 more source
Advanced Science, EarlyView.IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu +10 more
wiley +1 more source
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source