Results 121 to 130 of about 258,313 (263)

The nuclear receptor TR4 orchestrates cytoskeletal organization in a Gα12/ROCK‐dependent manner to promote myofibroblast differentiation and tissue fibrosis in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of the testicular receptor 4 (TR4, or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated.
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

COST1 stimulates RHD3 GTPase activity to maintain ER morphology and plant growth in <i>Arabidopsis</i>. [PDF]

Sci Adv
Wang J, Jiang J, Ren J, Zhao Y, Zhang Y, Feng D, Li Y, Zhang Q, Niu Y, Zhang X, Xu K, Sun J, Wang P, Zheng H, Bassham DC, Wang C, Hu J, Bao Y.   +17 more
europepmc   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Genome-wide identification of small GTPase gene family members in <i>Lentinula edodes</i> and the roles of <i>LeRho1</i> in biotic and abiotic stress responses. [PDF]

Appl Environ Microbiol
Song J, Zhu T, Xu R, Yin H, Zhong H, Zhang J, Bian Y, Gong Y, Chen L, Zhou Y.   +9 more
europepmc   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, EarlyView.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Structural and biochemical basis of ROC-dependent activation of LRRK2. [PDF]

PNAS Nexus
Park Y, Wu C, Tennessen K, Wan L, Hoang NC, Hoang CW, Liao J, Hoang QQ.   +7 more
europepmc   +1 more source

Mutations in the PH Domain of DNM1 are associated with a nonepileptic phenotype characterized by developmental delay and neurobehavioral abnormalities [PDF]

, 2018
Araujo, Gabriel C, Brereton, Emily, Dodd, Jonathan, Fassi, Emily, Pathak, Sheel J, Shinawi, Marwan, Telegrafi, Aida   +6 more
core   +2 more sources

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Global molecular landscape of early MASLD progression in human obesity. [PDF]

Elife
Zhao Q, De Nardo W, Wang R, Zhong Y, Keles U, Sakalauskaite G, Zhao LN, Tay H, Youhanna S, Yan M, Xie Y, Kim Y, Lee S, Lim RL, Teo G, Narayanaswamy P, Burton PR, Lauschke VM, Choi H, Watt MJ, Kaldis P.   +20 more
europepmc   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source