Results 161 to 170 of about 259,262 (241)

ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs. [PDF]

Front Mol Biosci
Turn RE, Dacks JB, Rosenberg EM, Soubias O, Northup JK, Randazzo PA.   +5 more
europepmc   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Dimerization of ACAP4 is essential for its function in cell migration. [PDF]

J Mol Cell Biol
Ma H, He J, Fang Z, Xiong F, Zhao X, Wang D, Song X, Fu C, Urushidani T, Yao X, Qian H, Liu X.   +11 more
europepmc   +1 more source

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Classical and emergent insulin signaling dual changes in type 2 diabetes revealed by human iPSC-derived hepatocytes. [PDF]

J Diabetes Investig
Zheng S, Cui X, Wei R, Hong T.
europepmc   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

The ribosome derives the energy to translocate and unwind mRNA from EF-G binding. [PDF]

Nat Commun
Amiri H, Van Patten WJ, Rexroad G, Desai VP, Sterwerf BA, Lancaster L, Noller HF, Bustamante C.   +7 more
europepmc   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

The Conserved GTPase LepA May Contribute to the Final Proper Stabilization of the 3' Domain of the 30S Subunit During Ribosome Assembly. [PDF]

Int J Mol Sci
Kravchenko O, Maksimova E, Baymukhametov T, Eliseeva I, Stolboushkina E.   +4 more
europepmc   +1 more source