Results 171 to 180 of about 261,647 (345)

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

Mammalian Peptide Chain Termination, II. Codon Specificity and GTPase Activity of Release Factor

, 1971
Arthur L. Beaudet, C. Thomas Caskey
openalex   +1 more source

Chemigenetic Encoding of Fluorescent Dyes Enables High‐Fidelity and Wash‐Free Imaging of Proteins in Live Cells

Advanced Science, EarlyView.
This study develops a chemigenetic strategy that combines synthetic dyes with genetically encoded fluorescence for high‐fidelity, no‐wash protein imaging. By utilizing FRET between fluorescent proteins and Halo‐tag dyes, this system ensures that only target‐bound dyes fluoresce, effectively suppressing background signals and enhancing the signal‐to ...
Xuelian Zhou, Lu Miao, Ning Xu, Yonghui Chen, Jinjing Shi, Jinhua Zhou, Guangying Wang, Qinglong Qiao, Zhaochao Xu   +8 more
wiley   +1 more source

Requirement of Proteins S5 and S9 from 30S Subunits for the Ribosome-Dependent GTPase Activity of Elongation Factor G

, 1973
Robert C. Marsh, Andrea Parmeggiani
openalex   +1 more source

Differential Regulation of Cellular Activities by GTPase-Activating Protein and NF1 [PDF]

, 1993
Nadia Al-Alawi, Gangfeng Xu, R. White, Robin Clark, Frank McCormick, James R. Feramisco   +5 more
openalex   +1 more source

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway

Advanced Science, EarlyView.
This study identifies STAU2 as an oncogenic RNA‐binding protein (RBP) with elevated expression in pancreatic ductal adenocarcinoma (PDAC), where its high levels are significantly correlated with metastatic progression. It elucidates that STAU2 directly binds and regulates PALLD, while mediating the functional role of IQGAP1, thereby driving metastasis ...
Jiayu Ding, Hao Shen, Jiaying Ji, Jiaxing Li, Zhongrui Shi, Xuejiao Wang, Bangbang Li, Yi Hou, Wenjian Min, Chengliang Sun, Kai Yuan, Yasheng Zhu, Liping Wang, Shun‐Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang   +16 more
wiley   +1 more source

Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an “excited” state of GTPase is a control component of the system.

, 1977
Marc Rendell, Martin Rodbell, Marvin I. Berman   +2 more
openalex   +1 more source

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells [PDF]

, 1994
Ahmed Zahraoui, Gérard Joberty, Monique Arpin, J Fontaine, Raymond Hellio, A Tavitian, Daniel Louvard   +6 more
openalex   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source