Results 181 to 190 of about 246,437 (319)
Differential Regulation of Cellular Activities by GTPase-Activating Protein and NF1 [PDF]
, 1993 Nadia Al-Alawi +5 more
openalex +1 more source
Interaction Between Actin and Microtubules During Plant Development
Cytoskeleton, EarlyView.ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu +3 more
wiley +1 more source
Environmental Toxicology, Volume 38, Issue 1, Page 90-100, January 2023., 2023 Abstract Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair enzyme methyl guanine methyltransferase (MGMT), which removes methyl groups from purine bases, counteracts
Ai Mai +6 more
wiley +1 more source
The Plant Genome, Volume 15, Issue 4, December 2022., 2022 Abstract As an important family of pathogenesis‐related (PR) proteins, the functional diversification and roles of PR10s in biotic stress have been well documented. However, the molecular basis of PR10s in plant defense responses against pathogens remains to be further understood.
Jin Guo +6 more
wiley +1 more source
Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members. [PDF]
, 1994 Paolo Fedi +3 more
openalex +1 more source
Small‐Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation
ChemMedChem, Accepted Article.The development of the KRAS G12C inhibitor sotorasib was a major advance towards drugging KRAS. However, the G12C mutation is only found in about 10% of tumors with a KRAS mutation. KRAS tyrosine amino acids could provide alternative sites for covalent drug development.
Alexander Landgraf +5 more
wiley +1 more source
ATPase and GTPase activities associated with Semliki Forest virus nonstructural protein nsP2 [PDF]
, 1994 M Rikkonen +2 more
openalex +1 more source
Nondegradative Synthetic Molecular Glues Enter the Clinic
ChemMedChem, EarlyView.Proximity‐inducing drugs are a novel therapeutic modality and currently mainly focused on target degradation. Recently, nondegradative molecular glues, inspired by natural products that reprogram cyclophilin A (Cyp A) to inhibit K‐Ras, have entered the clinic.
Maximilian L. Repity +2 more
wiley +1 more source
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
, 1992 Cecilia Bucci +6 more
openalex +1 more source
ChemMedChem, Accepted Article.ROR1 kinase is an underexplored promising target for the development of novel anticancer drugs, being strongly expressed in several cancer cell lines, but poorly in non‐tumor cells. This property, together with the scarce number of molecules effective against ROR1, led us to design and develop a research program aimed to the discovery of new chemical ...
Gerardina Smaldone +17 more
wiley +1 more source