Results 191 to 200 of about 259,262 (241)

Asymmetric Parietal Cortical Atrophy in a Patient with RAB39B‐Associated Parkinsonism

Movement Disorders Clinical Practice, EarlyView.
Luca Gallo, Emna Ben Mansour, Silvia Nicolosi, Anna Pichiecchio, Simone Gana, Samia Ben Sassi, Silvano Cristina, Micol Avenali, Enza Maria Valente   +8 more
wiley   +1 more source

Deciphering the Heterogeneity of Pulmonary Macrophages in Response to Fine Particles

Small, EarlyView.
This study introduces a dual‐labeled gold nanoparticle model to capture particle–responsive cells via integrating fluorescence‐activated cell sorting and single‐cell RNA sequencing. Fourteen macrophage subsets are identified with response and function heterogeneity, among which AMs_3, AMs_7, and recMacs_4 subsets show stronger phagocytic activation ...
Qing'e Shan, Zheng Dong, Ning Li, Zijie Zhou, Jiayu Ren, Wei Liu, Feng Xu, Yu Qi, Juan Ma, Yi Liu, Shuping Zhang, Sijin Liu   +11 more
wiley   +1 more source

Methods for Controlling Small GTPase Activity. [PDF]

Chembiochem
Faulkner B, He Y, Sitrin D, Stains CI.
europepmc   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, EarlyView.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

Functional identification of two variants in unrelated Chinese patients with DNM1L-related mitochondrial disorders. [PDF]

BMC Pediatr
Zhang Z, Chen Z, Bie X, Xie Z, Li X, Liu J, Xiao M, Zhang Q, Zhang Y, Yang Y, Li D.   +10 more
europepmc   +1 more source

A multimodal deep learning framework for predicting sunitinib response in advanced clear cell renal cell carcinoma

VIEW, EarlyView.
In this study, we constructed a prognostic model for ccRCC patients treated with Sunitinib through a deep learning‐based multimodal approach. Our CGPR model further confirms the feasibility of integrating multimodal and provides guidance for future tumor patients to receive precision therapy.
Xi Tian, Yuchen Jiang, Shuxuan Zhu, Xiaohang Liu, Aihetaimujiang Anwaier, Shiqi Ye, Kun Chang, Yuanyuan Qu, Ya‐Jia Gu, Hailiang Zhang, Dingwei Ye, Wenhao Xu   +11 more
wiley   +1 more source

Botulinum neurotoxin Light Chain/A1 uses fast synaptic vesicle cycling to cleave plasma membrane bound SNAP-25. [PDF]

Commun Biol
Gardner A, Sneller M, Tepp WH, Barbieri JT, Pellett S.   +4 more
europepmc   +1 more source

Mass spectrometry‐based mitochondrial proteomics for cancer biomarker discovery

VIEW, EarlyView.
Figure.1 Schematic diagram of MS‐based mitochondrial proteomics for cancer biomarker discovery. The workflow highlights the integration of advanced technological platforms in mitochondrial proteomics and their application in cancer biomarker discovery.
Zheng Cao, ZiKun Song, Weijie Zhou, Xiaohui Liu, Yanling Liu, Peng R. Chen, Kun Qian   +6 more
wiley   +1 more source

Computational model predicts function of Rho-GTPase binding for plexin receptor GAP activity on Rap1b via dynamic allosteric changes. [PDF]

Protein Sci
Bhattarai N, Morrison L, Gomes AF, Savage P, Sahoo AR, Buck M.   +5 more
europepmc   +1 more source

The molecular mechanisms and physiological roles of mitochondria dynamics in <i>Saccharomyces cerevisiae</i>. [PDF]

Microb Cell
Chen CL, Huang WL, Rapoport A, Daugelavičius R, Chang CR.   +4 more
europepmc   +1 more source