Results 191 to 200 of about 246,437 (319)
Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
A little less aggregation a little more replication: Viral manipulation of stress granules
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley +1 more source
Various methods to detect small GTPase activation: from radioisotope-based methods to the Small GTPase ActIvitY ANalysing (SAIYAN) system. [PDF]
J BiochemMaeda M, Saito K.
europepmc +1 more source
The RGG motif proteins: Interactions, functions, and regulations
WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023 RGG motif proteins play vital roles in the translation process from mRNA transport to translational regulation. Functions of RGG motif proteins depend on their ability to bind to RNAs and proteins, localize to various compartments of the cell and post‐translational modifications.
Mashiat N. Chowdhury, Hong Jin
wiley +1 more source
Activation of RHO-GTPase gene pattern correlates with adverse clinical outcome and immune microenvironment in clear cell renal cell carcinoma. [PDF]
Clin Exp MedGuo K +7 more
europepmc +1 more source
European Journal of Heart Failure, EarlyView.Heart failure (HF) with supranormal ejection fraction (HFsnEF) is an unnoticed but emerging entity in HF. This study showed that HFsnEF carries a similarly increased cardiovascular risk as HF with reduced ejection fraction (HFrEF) and distinct structural and proteomic characteristics from HFrEF, warranting a further comprehensive understanding and ...
Yasuhiko Sakata +19 more
wiley +1 more source
FASEB BioAdvances, Volume 4, Issue 12, Page 775-797, December 2022., 2022 Abstract During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface.
Alba Rudolf Vegas +6 more
wiley +1 more source
The biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning. [PDF]
EMBO JArmstrong MC +9 more
europepmc +1 more source