Results 21 to 30 of about 4,730 (218)
Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling
Viruses, 2011 Herpesviruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gammaherpesvirus subfamilies.
Herman W. Favoreel +1 more
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Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. [PDF]
PLoS ONE, 2013 Dynamin is the most-studied membrane fission machinery and has served as a paradigm for studies of other fission GTPases; however, several critical questions regarding its function remain unresolved.
Ya-Wen Liu +2 more
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GTPases and the origin of the ribosome [PDF]
Biology Direct, 2010 This paper is an attempt to trace the evolution of the ribosome through the evolution of the universal P-loop GTPases that are involved with the ribosome in translation and with the attachment of the ribosome to the membrane. The GTPases involved in translation in Bacteria/Archaea are the elongation factors EFTu/EF1, the initiation factors IF2/aeIF5b +
Smith, Temple F., Hartman, Hyman
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F1000Research, 2016 Rho GTPases are crucial signaling molecules that regulate a plethora of biological functions. Traditional biochemical, cell biological, and genetic approaches have founded the basis of Rho GTPase biology.
Rafael Dominik Fritz, Olivier Pertz
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eLife, 2020 Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and ...
Alfonso Bolado-Carrancio +8 more
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Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling
Cells, 2023 Rho-GTPases are central regulators within a complex signaling network that controls cytoskeletal organization and cell movement. The network includes multiple GTPases, such as the most studied Rac1, Cdc42, and RhoA, along with their numerous effectors ...
Siarhei Hladyshau +4 more
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Rho Family GTPases in Fission Yeast Cytokinesis
Communicative & Integrative Biology, 2019 During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow.
Brian Hercyk, Maitreyi Das
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The ROP2 GTPase Participates in Nitric Oxide (NO)-Induced Root Shortening in Arabidopsis
Plants, 2023 Nitric oxide (NO) is a versatile signal molecule that mediates environmental and hormonal signals orchestrating plant development. NO may act via reversible S-nitrosation of proteins during which an NO moiety is added to a cysteine thiol to form an S ...
Erzsébet Kenesi +11 more
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ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]
PLoS ONE, 2010 Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig +8 more
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Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. [PDF]
PLoS Computational Biology, 2006 Formation of multiprotein complexes on cellular membranes is critically dependent on the cyclic activation of small GTPases. FRAP-based analyses demonstrate that within protein complexes, some small GTPases cycle nearly three orders of magnitude faster ...
Andrew B Goryachev, Alexandra V Pokhilko
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