Results 21 to 30 of about 188,398 (263)
Small GTPases in platelet membrane trafficking
Platelets, 2019 Our understanding of fundamental biological processes within platelets is continually evolving. A critical feature of platelet biology relates to the intricate uptake, packaging and release of bioactive cargo from storage vesicles, essential in mediating
Tony G. Walsh +3 more
doaj +1 more source
Plant Protection Science, 2002 Small G-proteins (RAC and RHO) are known to be involved in regulation of superoxide (O2*-) production and the assembly of actin fibres. These processes are known to be crucial for accessibility and inaccessibility of barley cells to the biotrophic fungus
H. Schultheiss +3 more
doaj +1 more source
Dynamin-catalyzed membrane fission requires coordinated GTP hydrolysis. [PDF]
PLoS ONE, 2013 Dynamin is the most-studied membrane fission machinery and has served as a paradigm for studies of other fission GTPases; however, several critical questions regarding its function remain unresolved.
Ya-Wen Liu +2 more
doaj +1 more source
Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B [PDF]
, 2010 Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa.
Langsley, G +20 more
core +1 more source
eLife, 2020 Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and ...
Alfonso Bolado-Carrancio +8 more
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Spatiotemporal Coordination of Rac1 and Cdc42 at the Whole Cell Level during Cell Ruffling
Cells, 2023 Rho-GTPases are central regulators within a complex signaling network that controls cytoskeletal organization and cell movement. The network includes multiple GTPases, such as the most studied Rac1, Cdc42, and RhoA, along with their numerous effectors ...
Siarhei Hladyshau +4 more
doaj +1 more source
Rho Family GTPases in Fission Yeast Cytokinesis
Communicative & Integrative Biology, 2019 During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow.
Brian Hercyk, Maitreyi Das
doaj +1 more source
The ROP2 GTPase Participates in Nitric Oxide (NO)-Induced Root Shortening in Arabidopsis
Plants, 2023 Nitric oxide (NO) is a versatile signal molecule that mediates environmental and hormonal signals orchestrating plant development. NO may act via reversible S-nitrosation of proteins during which an NO moiety is added to a cysteine thiol to form an S ...
Erzsébet Kenesi +11 more
doaj +1 more source
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies [PDF]
, 2008 Mutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of
Hurd, Toby W +8 more
core +1 more source
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]
PLoS ONE, 2010 Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig +8 more
doaj +1 more source