Results 31 to 40 of about 4,730 (218)
Fixing the GAP: The role of RhoGAPs in cancer
European Journal of Cell Biology, 2022 Cancer progression and metastasis are processes that involve significant cellular changes. Many of these changes include alterations in the activity of the Rho GTPase family of proteins.
Gabriel Kreider-Letterman +2 more
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Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast
Scientific Reports, 2017 The final step in post-translational processing of Ras and Rho GTPases involves methylation of the prenylated cysteine residue by an isoprenylcysteine-O-carboxyl methyltransferase (ICMT).
Alejandro Franco +9 more
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The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory
Frontiers in Synaptic Neuroscience, 2020 The ability to form memories in the brain is needed for daily functions, and its impairment is associated with human mental disorders. Evidence indicates that long-term memory (LTM)-related processes such as its consolidation, extinction and forgetting ...
Joana Freitas Costa +2 more
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Veterinary Research, 2023 The alphaherpesvirus pseudorabies virus (PRV) is the causative agent of pseudorabies, responsible for severe economic losses to the swine industry worldwide.
Xiaohua Zhang +7 more
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Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation
Frontiers in Cellular and Infection Microbiology, 2022 Irgb6 is a member of interferon γ-induced immunity related GTPase (IRG), and one of twenty “effector” IRGs, which coordinately attack parasitophorous vacuole membrane (PVM), causing death of intracellular pathogen.
Hiroshi Yamada +6 more
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Journal of Cell Science, 2007 It has been two decades since the yeast Ypt1 and Sec4 proteins and the mammalian Rab (Ras-related proteins in brain) GTPases were first identified as evolutionarily conserved, essential regulators of membrane trafficking ([Salminen and Novick, 1987][1]; [Schmitt et al., 1986][2]; [Touchot et al.,
Schwartz, Samantha +4 more
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Cell Reports, 2023 Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher ...
Capria Rinaldi +8 more
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Review: Translational GTPases [PDF]
Biopolymers, 2016 ABSTRACTTranslational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome. Despite the high degree of evolutionary conservation in the sequences of their GTP‐binding domains, the rates of GTP hydrolysis and nucleotide exchange vary broadly between different trGTPases.
Maracci, Cristina, Rodnina, Marina V.
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
ANLN Directly Interacts with RhoA to Promote Doxorubicin Resistance in Breast Cancer Cells
Cancer Management and Research, 2020 Feng Wang,* Zhen Xiang,* Teng Huang,* Min Zhang, Wei-Bing Zhou Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ...
Wang F +4 more
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