Results 1 to 10 of about 6,079 (194)

The effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model [PDF]

Journal of Orthopaedic Translation, 2023
Background: Although neuroregulation plays an important role in tissue healing, the key neuroregulatory pathways and related neurotransmitters involved in bone-tendon interface (BTI) healing are still unknown.
Tingmo Huang, Liyang Wan, Yang Chen, Yinghong Xiong, Feifei Yuan, Shanshan Xie, Jianjun Huang, Hongbin Lu   +7 more
doaj   +2 more sources

Guanethidine Restores Tetracycline Sensitivity in Multidrug-Resistant Escherichia coli Carrying tetA Gene [PDF]

Antibiotics
The worrying issue of antibiotic resistance in pathogenic bacteria is aggravated by the scarcity of novel therapeutic agents. Antibiotic adjuvants offer a promising solution due to their cost-effectiveness and high efficacy in addressing this issue, such
Xiaoou Zhao, Mengna Zhang, Zhendu Zhang, Lei Wang, Yu Wang, Lizai Liu, Duojia Wang, Xin Zhang, Luobing Zhao, Yunhui Zhao, Xiangshu Jin, Xiaoxiao Liu, Hongxia Ma   +12 more
doaj   +2 more sources

Guanethidine Enhances the Antibacterial Activity of Rifampicin Against Multidrug-Resistant Bacteria [PDF]

Microorganisms
The escalating global threat of antibiotic resistance necessitates innovative strategies, such as the combination of antibiotics with adjuvants. Monotherapy with rifampicin is more likely to induce resistance in pathogens compared to other antibiotics ...
Xiaoou Zhao, Zhendu Zhang, Lizai Liu, Duojia Wang, Xin Zhang, Luobing Zhao, Yunhui Zhao, Xiangshu Jin, Lei Wang, Xiaoxiao Liu   +9 more
doaj   +2 more sources

Sympathectomy Effects on Intra-Abdominal Organ Catecholamine Levels in a Streptozotocin-Induced Diabetic Rat Model [PDF]

Life, 2022
Diabetes mellitus (DM) is a metabolic disorder whose prevalence has continuously increased worldwide and is associated with dysfunction of the autonomic nervous system and, in particular, that of the sympathetic nervous system (SNS).
Angélica Pérez-Juárez, Andrea Giovanna Aguirre-Pérez, Cornelio Barrientos-Alvarado   +2 more
doaj   +2 more sources

Comprehensive analysis of SLC43A2 on the tumor immune microenvironment and prognosis of liver hepatocellular carcinoma [PDF]

Frontiers in Genetics, 2022
Background: Tumor cells outcompete T cells for methionine via overexpressing SLC43A2, causing T cells exhaustion. We explored the influence of SLC43A2 on tumor immune microenvironment (TIME), immune-related genes (IRGs) and the prognosis of liver ...
Yan Liao, Yan Liao, Junmei Weng, Lian Chen, Nan Hu, Xun Yuan, Jianhua Wang, Feng He, Yixin Cai, Qin Huang, Jianing Wang, Liu Huang   +11 more
doaj   +2 more sources

Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain [PDF]

Molecular Pain, 2007
Background Clinical and experimental studies of neuropathic pain support the hypothesis that a functional coupling between postganglionic sympathetic efferent and sensory afferent fibers contributes to the pain.
Beggah Ahmed T, Allchorne Andrew J, Pertin Marie, Woolf Clifford J, Decosterd Isabelle   +4 more
doaj   +3 more sources

Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation [PDF]

Frontiers in Physiology
IntroductionIn the present study we aim to determine the effects of different inhibitors of the late sodium current (INa,late) on vascular responses to adrenergic stimuli, both endogenous and exogenous.MethodsThe study was performed using specific ...
Maria Dolores Mauricio, Adrian Jorda, Solanye Guerra-Ojeda, Jose M. Vila, Soraya L. Valles, Martin Aldasoro   +5 more
doaj   +2 more sources

Bolus Injection of Liraglutide Raises Plasma Glucose in Normal Rats by Activating Glucagon-like Peptide 1 Receptor in the Brain [PDF]

Pharmaceuticals, 2022
Diabetes is commonly treated with glucagon-like peptide-1 receptor (GLP-1R) agonists including liraglutide and others. However, liraglutide was found to raise plasma glucose levels in normal rats.
Chia-Chen Hsu, Juei-Tang Cheng, Ping Hao Hsu, Yingxiao Li, Kai-Chun Cheng   +4 more
doaj   +2 more sources

Deep learning-based discovery of compounds for blood pressure lowering effects [PDF]

Scientific Reports
The hypotensive side effects caused by drugs during their use have been a vexing issue. Recent studies have found that deep learning can effectively predict the biological activity of compounds by mining patterns and rules in the data, providing a ...
Rongzhen Li, Tianchi Wu, Xiaotian Xu, Xiaoqun Duan, Yuhui Wang   +4 more
doaj   +2 more sources

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration [PDF]

, 2016
Background: Parkinson's disease (PD) is frequently associated with gastrointestinal (GI) symptoms, including constipation and defecatory dysfunctions. The mechanisms underlying such disorders are still largely unknown, although the occurrence of a bowel ...
Antonioli, Luca, Bernardini, Nunzia, Blandini, Fabio, Blandizzi, Corrado, Cerri, Silvia, Colucci, ROCCHINA LUCIA, Cseri, Karolina, Fornai, Matteo, Hask\uf3, Gy\uf6rgy, Ippolito, Chiara, Levandis, Giovanna, Pellegrini, Carolina, Segnani, Cristina, Tirotta, Erika   +13 more
core   +6 more sources