Results 151 to 160 of about 68,963 (231)

Guanidines: Privileged Scaffolds Against Neglected Tropical Diseases: A Review. [PDF]

Pharmaceuticals (Basel)
Dos Anjos LR, de Araújo RSA, Dos Reis MML, Costa NCS, Bernardo VG, Zampieri EH, Rodrigues KADF, Cilli EM, González ERP, Mendonça-Junior FJB.   +9 more
europepmc   +1 more source

Automated Multienzyme Digestion Workflows for Confident Characterization of Challenging Posttranslational Modifications in Therapeutic Antibodies by LC–MS/MS

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Non‐reduced trypsin digestion of therapeutic antibodies can generate large disulfide‐linked peptide complexes that exhibit poor chromatographic and mass spectrometric performance. This limits the confident characterization of posttranslational modifications (PTMs) in specific antibody regions, such as the heavy‐chain constant region ...
Nanna Sofie Eskesen, Yann Leblanc, Justine Lempereur, Martin Ørgaard, Elizabeta Madzharova, Trine M. Sloth, Simon Krabbe, Alexandra K. Rebak, Magali André, Pernille F. Jensen, Dan B. Kristensen   +10 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

De Novo Discovery of Nonstandard Thioisoindole‐Bridged Bicyclic Peptides Targeting Traf2‐ and NCK‐Interacting Kinase

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang, Alexander A. Vinogradov, Keisuke Hamada, Yin Sun, Toru Sengoku, Hiroaki Suga   +5 more
wiley   +2 more sources

Hydration Effects in a Guanidine Hydrochloride-Pyruvic Acid Low-Transition-Temperature Mixture: Physicochemical Insights. [PDF]

ACS Phys Chem Au
Sunil Kumar SN, Dash BR, Gardas RL.
europepmc   +1 more source

Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins

Protein Science, Volume 35, Issue 11, November 2026.
Abstract De novo protein design often produces thermostable proteins that denature above 100°C, which complicates the analysis of their stability. Thermostable proteins can be unfolded by combined chemical and thermal denaturation followed by global analysis of multiple melting curves.
Vili Lampinen, Osvaldo Burastero, Iara Plácido Guazzelli, Florian Vögele, Francisca Pinheiro, Jan S. Nowak, Maria M. Garcia Alai, Magnus Kjaergaard   +7 more
wiley   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

Immunology, Volume 179, Issue 3, Page 444-456, November 2026.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek   +5 more
wiley   +1 more source

A Wild Emmer Wheat B3 Transcription Factor Regulates Seed Growth and Nutrient Allocation

Plant, Cell &Environment, Volume 49, Issue 11, Page 7900-7910, November 2026.
ABSTRACT Seed weight (SW) and nutrient allocation are key determinants of yield and grain quality in wheat, yet the regulatory basis of naturally occurring variation in these traits remains poorly resolved. Wild emmer wheat (Triticum dicoccoides), the progenitor of modern wheat, retains extensive eco‐geographically structured genetic diversity that was
Davinder Sharma, Zechariah Haber, Manas R. Prusty, Raz Avni, Mijal Perez, Moshe Ronen, Rakesh Kumar, Arava Shatil‐Cohen, Paz Haboub, Chen Omer, Gilor Kelly, Hadar Aviv, Adi Doron‐Faigenboim, Din Moshe, Weronika Jasinska, Leah Rosental, Eitan Millet, Hanan Sela, Or Sperling, Amir Sharon, Anna Mintz Dub, Yariv Brotman, Nir Sade   +22 more
wiley   +1 more source

Validation of Guanidine-EDTA as a Preservative Agent for the Analysis of miRNAs and mRNAs in Blood Samples of Chagas Disease Patients. [PDF]

Pathogens
Faier-Pereira A, Finamore-Araujo P, Brito MMR, Hasslocher-Moreno AM, Moreira OC.   +4 more
europepmc   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source