Results 1 to 10 of about 7,960 (219)
mBio, 2017 In many bacterial species, the glycine riboswitch is composed of two homologous ligand-binding domains (aptamers) that each bind glycine and act together to regulate the expression of glycine metabolic and transport genes.
Arianne M. Babina +2 more
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Riboswitch-controlled lipid conversion enables functional membrane asymmetry in artificial cells [PDF]
Communications BiologyDynamic regulation of lipid membrane composition is fundamental to living cells; however, synthetic analogs capable of such regulation remain scarce. Here, we present an artificial cell platform in which riboswitch-mediated expression of phospholipase D (
Koki Kamiya, Sumin Lee, Kotaro Baba
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Cyclic Amide-Linked Oxazolidinone Triazoles as Inhibitors of the T-Box Riboswitch [PDF]
MoleculesAntimicrobial resistance remains a critical global health challenge, and was intensified by the COVID-19 pandemic. To address this growing threat, novel antibacterial agents targeting unconventional mechanisms are urgently needed.
Eric Parsons +6 more
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Designing molecular RNA switches with Restricted Boltzmann machines [PDF]
Nature CommunicationsRiboswitches are structured allosteric RNA molecules that change conformation upon metabolite binding, triggering a regulatory response. Here we focus on the de novo design of riboswitch-like aptamers, the core part of the riboswitch undergoing ...
Jorge Fernandez-de-Cossio-Diaz +8 more
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Frontiers in Molecular Biosciences, 2021 Short, structured fragments of non-coding mRNA may act as molecular switches upon binding specific ligands, regulating the translation of proteins encoded downstream this mRNA sequence.
Piotr Chyży +9 more
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Journal of Biological Engineering, 2021 Background Synthetic biological circuits are widely utilized to control microbial cell functions. Natural and synthetic riboswitches are attractive sensor modules for use in synthetic biology applications.
Yunhee Hwang +4 more
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TPP riboswitch-dependent regulation of an ancient thiamin transporter in Candida. [PDF]
PLoS Genetics, 2018 Riboswitches are non-coding RNA molecules that regulate gene expression by binding to specific ligands. They are primarily found in bacteria. However, one riboswitch type, the thiamin pyrophosphate (TPP) riboswitch, has also been described in some plants,
Paul D Donovan +6 more
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Computational study of unfolding and regulation mechanism of preQ1 riboswitches. [PDF]
PLoS ONE, 2012 Riboswitches are novel RNA regulatory elements. Each riboswitch molecule consists of two domains: aptamer and express platform. The three-dimensional (3D) structure of the aptamer domain, depending on ligand binding or not, controls that of the express ...
Zhou Gong +3 more
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A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity
RNA Biology, 2023 Riboswitches are regulatory RNAs that specifically bind a small molecule or ion. Like metabolite-binding proteins, riboswitches can evolve new ligand specificities, and some examples of this phenomenon have been validated.
Felina Lenkeit +5 more
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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. [PDF]
PLoS Pathogens, 2010 Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain.
Jérôme Mulhbacher +5 more
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