Results 21 to 30 of about 7,522 (226)
Riboswitch finder--a tool for identification of riboswitch RNAs [PDF]
Nucleic Acids Research, 2004 We describe a dedicated RNA motif search program and web server to identify RNA riboswitches. The Riboswitch finder analyses a given sequence using the web interface, checks specific sequence elements and secondary structure, calculates and displays the energy folding of the RNA structure and runs a number of tests including this information to ...
Peter Bengert, Thomas Dandekar
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Journal of Biological Engineering, 2021 Background Synthetic biological circuits are widely utilized to control microbial cell functions. Natural and synthetic riboswitches are attractive sensor modules for use in synthetic biology applications.
Yunhee Hwang +4 more
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Reconsidering the czcD (NiCo) Riboswitch as an Iron Riboswitch
ACS Bio & Med Chem Au, 2022 Recent work has proposed a new mechanism of bacterial iron regulation: riboswitches that undergo a conformational change in response to FeII. The czcD (NiCo) riboswitch was initially proposed to be specific for NiII and CoII, but we recently showed via a czcD-based fluorescent sensor that FeII is also a plausible physiological ligand for this ...
Jiansong Xu, Joseph A. Cotruvo
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A Decade of Riboswitches [PDF]
Cell, 2013 Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability.
Serganov, Alexander, Nudler, Evgeny
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TPP riboswitch-dependent regulation of an ancient thiamin transporter in Candida. [PDF]
PLoS Genetics, 2018 Riboswitches are non-coding RNA molecules that regulate gene expression by binding to specific ligands. They are primarily found in bacteria. However, one riboswitch type, the thiamin pyrophosphate (TPP) riboswitch, has also been described in some plants,
Paul D Donovan +6 more
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Computational study of unfolding and regulation mechanism of preQ1 riboswitches. [PDF]
PLoS ONE, 2012 Riboswitches are novel RNA regulatory elements. Each riboswitch molecule consists of two domains: aptamer and express platform. The three-dimensional (3D) structure of the aptamer domain, depending on ligand binding or not, controls that of the express ...
Zhou Gong +3 more
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A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity
RNA Biology, 2023 Riboswitches are regulatory RNAs that specifically bind a small molecule or ion. Like metabolite-binding proteins, riboswitches can evolve new ligand specificities, and some examples of this phenomenon have been validated.
Felina Lenkeit +5 more
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Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. [PDF]
PLoS Pathogens, 2010 Riboswitches are regulatory elements modulating gene expression in response to specific metabolite binding. It has been recently reported that riboswitch agonists may exhibit antimicrobial properties by binding to the riboswitch domain.
Jérôme Mulhbacher +5 more
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Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis.
PLoS ONE, 2020 The oil palm (Elaeis guineensis) is an important crop in Malaysia but its productivity is hampered by various biotic and abiotic stresses. Recent studies suggest the importance of signalling molecules in plants in coping against stresses, which includes ...
Atiqah Subki +4 more
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Microbial Cell Factories, 2022 Background In vivo biosensors have a wide range of applications, ranging from the detection of metabolites to the regulation of metabolic networks, providing versatile tools for synthetic biology and metabolic engineering.
Kun-Qiang Hong +4 more
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