Results 21 to 30 of about 7,960 (219)
A Decade of Riboswitches [PDF]
Cell, 2013 Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability.
Serganov, Alexander, Nudler, Evgeny
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Reconsidering the czcD (NiCo) Riboswitch as an Iron Riboswitch [PDF]
, 2022 Recent work has proposed a new mechanism of bacterial iron regulation: riboswitches that undergo a conformational change in response to FeII. The czcD (NiCo) riboswitch was initially proposed to be specific for NiII and CoII, but we recently showed via a
Jiansong Xu +3 more
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Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]
, 2010 Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Wöhnert, Jens +2 more
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Communications Biology, 2022 Molecular dynamic simulations are employed to assess the influence of metal ions on riboswitch structure and dynamics, suggesting a conformational control of riboswitch aptamers by metal ions before ligand binding.
Lei Bao, Wen-Bin Kang, Yi Xiao
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Development of a novel tobramycin dependent riboswitch [PDF]
, 2023 We herein report the selection and characterization of a new riboswitch dependent on the aminoglycoside tobramycin. Its dynamic range rivals even the tetracycline dependent riboswitch to be the current best performing, synthetic riboswitch that controls ...
Simon Fürbacher +21 more
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Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis.
PLoS ONE, 2020 The oil palm (Elaeis guineensis) is an important crop in Malaysia but its productivity is hampered by various biotic and abiotic stresses. Recent studies suggest the importance of signalling molecules in plants in coping against stresses, which includes ...
Atiqah Subki +4 more
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Dissecting the influence of Mg2+ on 3D architecture and ligand-binding of the guanine-sensing riboswitch aptamer domain [PDF]
, 2010 Long-range tertiary interactions determine the three-dimensional structure of a number of metabolite-binding riboswitch RNA elements and were found to be important for their regulatory function. For the guanine-sensing riboswitch of the Bacillus subtilis
Wöhnert, Jens +3 more
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Microbial Cell Factories, 2022 Background In vivo biosensors have a wide range of applications, ranging from the detection of metabolites to the regulation of metabolic networks, providing versatile tools for synthetic biology and metabolic engineering.
Kun-Qiang Hong +4 more
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Frontiers in Molecular Biosciences, 2022 Riboswitch RNAs regulate gene expression by conformational changes induced by environmental conditions and specific ligand binding. The guanidine-II riboswitch is proposed to bind the small molecule guanidinium and to subsequently form a kissing loop ...
Christin Fuks +4 more
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Cell, 2006 Riboswitches are common cis-acting regulatory elements in bacteria. They are made of nascent RNA that changes its conformation in response to direct binding of cognate metabolites. The publication of five high-resolution crystal structures provides a comprehensive view of how riboswitches sense their ligands and points to new challenges in this ...
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